Tau-tubulin kinase 2 (EC 2.7.11.1)
1_MSGGG 6_ EQLDI 11_ LSVGI 16_ LVKER 21_ WKVLR 26_ KIGGG 31_ GFGEI 36_ YDALD 41_ MLTRE 46_ NVALK 51_ VESAQ 56_ QPKQV 61_ LKMEV 66_ AVLKK 71_ LQGKD 76_ HVCRF 81_ IGCGR 86_ NDRFN 91_ YVVMQ 96_ LQGRN 101_ LADLR 106_ RSQSR 111_ GTFTI 116_ STTLR 121_ LGRQI 126_ LESIE 131_ SIHSV 136_ GFLHR 141_ DIKPS 146_ NFAMG 151_ RFPST 156_ CRKCY 161_ MLDFG 166_ LARQF 171_ TNSCG 176_ DVRPP 181_ RAVAG 186_ FRGTV 191_ RYASI 196_ NAHRN 201_ REMGR 206_ HDDLW 211_ SLFYM 216_ LVEFV 221_ VGQLP 226_ WRKIK 231_ DKEQV 236_ GSIKE 241_ RYDHR 246_ LMLKH 251_ LPPEF 256_ SIFLD 261_ HISSL 266_ DYFTK 271_ PDYQL 276_ LTSVF 281_ DNSIK 286_ TFGVI 291_ ESDPF 296_ DWEKT 301_ GNDGS 306_ LTTTT 311_ TSTTP 316_ QLHTR 321_ LTPAA 326_ IGIAN 331_ ATPIP 336_ GDLLR 341_ ENTDE 346_ VFPDE 351_ QLSDG 356_ ENGIP 361_ VGVSP 366_ DKLPG 371_ SLGHP 376_ RPQEK 381_ DVWEE 386_ MDANK 391_ NKIKL 396_ GICKA 401_ ATEEE 406_ NSHGQ 411_ ANGLL 416_ NAPSL 421_ GSPIR 426_ VRSEI 431_ TQPDR 436_ DIPLV 441_ RKLRS 446_ IHSFE 451_ LEKRL 456_ TLEPK 461_ PDTDK 466_ FLETC 471_ LEKMQ 476_ KDTSA 481_ GKESI 486_ LPALL 491_ HKPCV 496_ PAVSR 501_ TDHIW 506_ HYDEE 511_ YLPDA 516_ SKPAS 521_ ANTPE 526_ QADGG 531_ GSNGF 536_ IAVNL 541_ SSCKQ 546_ EIDSK 551_ EWVIV 556_ DKEQD 561_ LQDFR 566_ TNEAV 571_ GHKTT 576_ GSPSD 581_ EEPEV 586_ LQVLE 591_ ASPQD 596_ EKLQL 601_ GPWAE 606_ NDHLK 611_ KETSG 616_ VVLAL 621_ SAEGP 626_ PTAAS 631_ EQYTD 636_ RLELQ 641_ PGAAS 646_ QFIAA 651_ TPTSL 656_ MEAQA 661_ EGPLT 666_ AITIP 671_ RPSVA 676_ STQST 681_ SGSFH 686_ CGQQP 691_ EKKDL 696_ QPMEP 701_ TVELY 706_ SPREN 711_ FSGLV 716_ VTEGE 721_ PPSGG 726_ SRTDL 731_ GLQID 736_ HIGHD 741_ MLPNI 746_ RESNK 751_ SQDLG 756_ PKELP 761_ DHNRL 766_ VVREF 771_ ENLPG 776_ ETEEK 781_ SILLE 786_ SDNED 791_ EKLSR 796_ GQHCI 801_ EISSL 806_ PGDLV 811_ IVEKD 816_ HSATT 821_ EPLDV 826_ TKTQT 831_ FSVVP 836_ NQDKN 841_ NEIMK 846_ LLTVG 851_ TSEIS 856_ SRDID 861_ PHVEG 866_ QIGQV 871_ AEMQK 876_ NKISK 881_ DDDIM 886_ SEDLP 891_ GHQGD 896_ LSTFL 901_ HQEGK 906_ REKIT 911_ PRNGE 916_ LFHCV 921_ SENEH 926_ GAPTR 931_ KDMVR 936_ SSFVT 941_ RHSRI 946_ PVLAQ 951_ EIDST 956_ LESSS 961_ PVSAK 966_ EKLLQ 971_ KKAYQ 976_ PDLVK 981_ LLVEK 986_ RQFKS 991_ FLGDL 996_ SSASD 1001_ KLLEE 1006_ KLATV 1011_ PAPFC 1016_ EEEVL 1021_ TPFSR 1026_ LTVDS 1031_ HLSRS 1036_ AEDSF 1041_ LSPII 1046_ SQSRK 1051_ SKIPR 1056_ PVSWV 1061_ NTDQV 1066_ NSSTS 1071_ SQFFP 1076_ RPPPG 1081_ KPPTR 1086_ PGVEA 1091_ RLRRY 1096_ KVLGS 1101_ SNSDS 1106_ DLFSR 1111_ LAQIL 1116_ QNGSQ 1121_ KPRST 1126_ TQCKS 1131_ PGSPH 1136_ NPKTP 1141_ PKSPV 1146_ VPRRS 1151_ PSASP 1156_ RSSSL 1161_ PRTSS 1166_ SSPSR 1171_ AGRPH 1176_ HDQRS 1181_ SSPHL 1186_ GRSKS 1191_ PPSHS 1196_ GSSSS 1201_ RRSCQ 1206_ QEHCK 1211_ PSKNG 1216_ LKGSG 1221_ SLHHH 1226_ SASTK 1231_ TPQGK 1236_SKPAS
1: Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (PubMed:30375385). Required for recruitment of CPLANE2 and INTU to the mother centriole (By similarity)