Grainyhead-like protein 2 homolog (Brother of mammalian grainyhead) (Transcription factor CP2-like 3)
1_MSQES 6_ DNNKR 11_ LVALV 16_ PMPSD 21_ PPFNT 26_ RRAYT 31_ SEDEA 36_ WKSYL 41_ ENPLT 46_ AATKA 51_ MMSIN 56_ GDEDS 61_ AAALG 66_ LLYDY 71_ YKVPR 76_ DKRLL 81_ SVSKA 86_ SDSQE 91_ DQEKR 96_ NCLGT 101_ SEAQS 106_ NLSGG 111_ ENRVQ 116_ VLKTV 121_ PVNLS 126_ LNQDH 131_ LENSK 136_ REQYS 141_ ISFPE 146_ SSAII 151_ PVSGI 156_ TVVKA 161_ EDFTP 166_ VFMAP 171_ PVHYP 176_ RGDGE 181_ EQRVV 186_ IFEQT 191_ QYDVP 196_ SLATH 201_ SAYLK 206_ DDQRS 211_ TPDST 216_ YSESF 221_ KDAAT 226_ EKFRS 231_ ASVGA 236_ EEYMY 241_ DQTSS 246_ GTFQY 251_ TLEAT 256_ KSLRQ 261_ KQGEG 266_ PMTYL 271_ NKGQF 276_ YAITL 281_ SETGD 286_ NKCFR 291_ HPISK 296_ VRSVV 301_ MVVFS 306_ EDKNR 311_ DEQLK 316_ YWKYW 321_ HSRQH 326_ TAKQR 331_ VLDIA 336_ DYKES 341_ FNTIG 346_ NIEEI 351_ AYNAV 356_ SFTWD 361_ VNEEA 366_ KIFIT 371_ VNCLS 376_ TDFSS 381_ QKGVK 386_ GLPLM 391_ IQIDT 396_ YSYNN 401_ RSNKP 406_ IHRAY 411_ CQIKV 416_ FCDKG 421_ AERKI 426_ RDEER 431_ KQNRK 436_ KGKGQ 441_ ASQTQ 446_ CNSSS 451_ DGKLA 456_ AIPLQ 461_ KKSDI 466_ TYFKT 471_ MPDLH 476_ SQPVL 481_ FIPDV 486_ HFANL 491_ QRTGQ 496_ VYYNT 501_ DDERE 506_ GGSVL 511_ VKRMF 516_ RPMEE 521_ EFGPV 526_ PSKQM 531_ KEEGT 536_ KRVLL 541_ YVRKE 546_ TDDVF 551_ DALML 556_ KSPTV 561_ KGLME 566_ AISEK 571_ YGLPV 576_ EKIAK 581_ LYKKS 586_ KKGIL 591_ VNMDD 596_ NIIEH 601_ YSNED 606_ TFILN 611_ MESMV 616_EGFKV
1: Transcription factor playing an important role in primary neurulation and in epithelial development (PubMed:25152456, PubMed:29309642). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (By similarity). During embryogenesis, plays unique and cooperative roles with GRHL3 in establishing distinct zones of primary neurulation. Essential for closure 3 (rostral end of the forebrain), functions cooperatively with GRHL3 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity). Regulates epithelial morphogenesis acting as a target gene-associated transcriptional activator of apical junctional complex components. Up-regulates of CLDN3 and CLDN4, as well as of RAB25, which increases the CLDN4 protein and its localization at tight junctions (By similarity). Comprises an essential component of the transcriptional machinery that establishes appropriate expression levels of CLDN4 and CDH1 in different types of epithelia. Exhibits functional redundancy with GRHL3 in epidermal morphogenetic events and epidermal wound repair (By similarity). In lung, forms a regulatory loop with NKX2-1 that coordinates lung epithelial cell morphogenesis and differentiation (By similarity). In keratinocytes, plays a role in telomerase activation during cellular proliferation, regulates TERT expression by binding to TERT promoter region and inhibiting DNA methylation at the 5'-CpG island, possibly by interfering with DNMT1 enzyme activity (PubMed:19015635, PubMed:20938050). In addition, impairs keratinocyte differentiation and epidermal function by inhibiting the expression of genes clustered at the epidermal differentiation complex (EDC) as well as GRHL1 and GRHL3 through epigenetic mechanisms (PubMed:23254293)