Mitochondrial sodium/calcium exchanger protein (Na(+)/K(+)/Ca(2+)-exchange protein 6) (Sodium/calcium exchanger protein, mitochondrial) (Sodium/potassium/calcium exchanger 6) (Solute carrier family 24 member 6) (Solute carrier family 8 member B1)
1_MAGRR 6_ LNLRW 11_ ALSVL 16_ CVLLM 21_ AETVS 26_ GTRGS 31_ STGAH 36_ ISPQF 41_ PASGV 46_ NQTPV 51_ VDCRK 56_ VCGLN 61_ VSDRC 66_ DFIRT 71_ NPDCH 76_ SDGGY 81_ LDYLE 86_ GIFCH 91_ FPPSL 96_ LPLAV 101_ TLYVS 106_ WLLYL 111_ FLILG 116_ VTAAK 121_ FFCPN 126_ LSAIS 131_ TTLKL 136_ SHNVA 141_ GVTFL 146_ AFGNG 151_ APDIF 156_ SALVA 161_ FSDPH 166_ TAGLA 171_ LGALF 176_ GAGVL 181_ VTTVV 186_ AGGIT 191_ ILHPF 196_ MAASR 201_ PFFRD 206_ IVFYM 211_ VAVFL 216_ TFLML 221_ FRGRV 226_ TLAWA 231_ LGYLG 236_ LYVFY 241_ VVTVI 246_ LCTWI 251_ YQRQR 256_ RGSLF 261_ CPMPV 266_ TPEIL 271_ SDSEE 276_ DRVSS 281_ NTNSY 286_ DYGDE 291_ YRPLF 296_ FYQET 301_ TAQIL 306_ VRALN 311_ PLDYM 316_ KWRRK 321_ SAYWK 326_ ALKVF 331_ KLPVE 336_ FLLLL 341_ TVPVV 346_ DPDKD 351_ DQNWK 356_ RPLNC 361_ LHLVI 366_ SPLVV 371_ VLTLQ 376_ SGTYG 381_ VYEIG 386_ GLVPV 391_ WVVVV 396_ IAGTA 401_ LASVT 406_ FFATS 411_ DSQPP 416_ RLHWL 421_ FAFLG 426_ FLTSA 431_ LWINA 436_ AATEV 441_ VNILR 446_ SLGVV 451_ FRLSN 456_ TVLGL 461_ TLLAW 466_ GNSIG 471_ DAFSD 476_ FTLAR 481_ QGYPR 486_ MAFSA 491_ CFGGI 496_ IFNIL 501_ VGVGL 506_ GCLLQ 511_ ISRSH 516_ TEVKL 521_ EPDGL 526_ LVWVL 531_ AGALG 536_ LSLVF 541_ SLVSV 546_ PLQCF 551_ QLSRV 556_ YGFCL 561_ LLFYL 566_ NFLVV 571_ ALLTE 576_FGVIH
1: Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:15060069, PubMed:20018762, PubMed:22829870, PubMed:23056385, PubMed:24898248, PubMed:28130126, PubMed:28219928). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (By similarity). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (PubMed:23056385). Required for store-operated Ca(2+) entry (SOCE) and Ca(2+) release-activated Ca(2+) (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (PubMed:28219928). Involved in B-lymphocyte chemotaxis (By similarity). Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange (PubMed:15060069, PubMed:28130126). In contrast to other members of the family its function is independent of K(+) (PubMed:15060069)