Tyrosine-protein kinase STYK1 (EC 2.7.10.2) (Novel oncogene with kinase domain) (Protein PK-unique) (Serine/threonine/tyrosine kinase 1)
1_MGMTR 6_ MLLEC 11_ SLSDK 16_ LCVIQ 21_ EKQYE 26_ VIIVP 31_ TLLVT 36_ IFLIL 41_ LGVIL 46_ WLFIR 51_ EQRTQ 56_ QQRSG 61_ PQGIA 66_ PVPPP 71_ RDLSW 76_ EAGHG 81_ GNVAL 86_ PLKET 91_ SVENF 96_ LGATT 101_ PALAK 106_ LQVPR 111_ EQLSE 116_ VLEQI 121_ CSGSC 126_ GPIFR 131_ ANMNT 136_ GDPSK 141_ PKSVI 146_ LKALK 151_ EPAGL 156_ HEVQD 161_ FLGRI 166_ QFHQY 171_ LGKHK 176_ NLVQL 181_ EGCCT 186_ EKLPL 191_ YMVLE 196_ DVAQG 201_ DLLSF 206_ LWTCR 211_ RDVMT 216_ MDGLL 221_ YDLTE 226_ KQVYH 231_ IGKQV 236_ LLALE 241_ FLQEK 246_ HLFHG 251_ DVAAR 256_ NILMQ 261_ SDLTA 266_ KLCGL 271_ GLAYE 276_ VYTRG 281_ AISST 286_ QTIPL 291_ KWLAP 296_ ERLLL 301_ RPASI 306_ RADVW 311_ SFGIL 316_ LYEMV 321_ TLGAP 326_ PYPEV 331_ PPTSI 336_ LEHLQ 341_ RRKIM 346_ KRPSS 351_ CTHTM 356_ YSIMK 361_ SCWRW 366_ READR 371_ PSPRE 376_ LRLRL 381_ EAAIK 386_ TADDE 391_ AVLQV 396_ PELVV 401_ PELYA 406_ AVAGI 411_ RVESL 416_FYNYS
1: Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity)