Pyrin and HIN domain-containing protein 1 (Interferon-inducible protein X)
1_MANNY 6_ KKIVL 11_ LKGLE 16_ VINDY 21_ HFRIV 26_ KSLLS 31_ NDLKL 36_ NPKMK 41_ EEYDK 46_ IQIAD 51_ LMEEK 56_ FPGDA 61_ GLGKL 66_ IEFFK 71_ EIPTL 76_ GDLAE 81_ TLKRE 86_ KLKVA 91_ NKIES 96_ IPVKG 101_ IIPSK 106_ KTKQK 111_ EVYPA 116_ TPACT 121_ PSNRL 126_ TAKGA 131_ EETLG 136_ PQKRK 141_ KPSEE 146_ ETGTK 151_ RSKMS 156_ KEQTR 161_ PSCSA 166_ GASTS 171_ TAMGR 176_ SPPPQ 181_ TSSSA 186_ PPNTS 191_ STESL 196_ KPLAN 201_ RHATA 206_ SKNIF 211_ REDPI 216_ IAMVL 221_ NATKV 226_ FKYES 231_ SENEQ 236_ RRMFH 241_ ATVAT 246_ QTQFF 251_ HVKVL 256_ NINLK 261_ RKFIK 266_ KRIII 271_ ISNYS 276_ KRNSL 281_ LEVNE 286_ ASSVS 291_ EAGPD 296_ QTFEV 301_ PKDII 306_ RRAKK 311_ IPKIN 316_ ILHKQ 321_ TSGYI 326_ VYGLF 331_ MLHTK 336_ IVNRK 341_ TTIYE 346_ IQDKT 351_ GSMAV 356_ VGKGE 361_ CHNIP 366_ CEKGD 371_ KLRLF 376_ CFRLR 381_ KRENM 386_ SKLMS 391_ EMHSF 396_ IQIQK 401_ NTNQR 406_ SHDSR 411_ SMALP 416_ QEQSQ 421_ HPKPS 426_ EASTT 431_ LPESH 436_ LKTPQ 441_ MPPTT 446_ PSSSS 451_ FTKKD 456_ ETHPG 461_ AQSSP 466_ ANFRI 471_ TSPTV 476_ APPLS 481_ SDTST 486_NRHPA
1: Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells