2',5'-phosphodiesterase 12 (2'-PDE) (2-PDE) (EC 3.1.4.-) (Mitochondrial deadenylase) (EC 3.1.13.4)
1_MWRLP 6_ GARAA 11_ LRVIR 16_ TAVEK 21_ LSRAE 26_ AGSQT 31_ AAGAM 36_ ERAVV 41_ RCVPS 46_ EPKLS 51_ LSFAL 56_ ADGSH 61_ KNMQR 66_ DQSEP 71_ LGRVL 76_ SRIAT 81_ NALKG 86_ HAKAA 91_ AAKKS 96_ RKSRP 101_ NASGG 106_ AACSG 111_ PGPEP 116_ AVFCE 121_ PVVKL 126_ YYREE 131_ AVAED 136_ VLNVD 141_ AWQDG 146_ AVLQI 151_ GDVKY 156_ KVERN 161_ PPAFT 166_ ELQLP 171_ RYIMA 176_ GFPVC 181_ PKLSL 186_ EFGDP 191_ ASSLF 196_ RWYKE 201_ AKPGA 206_ AEPEV 211_ GVPSS 216_ LSPSS 221_ PSSSW 226_ TETDV 231_ EERVY 236_ TPSNA 241_ DIGLR 246_ LKLHC 251_ TPGDG 256_ QRFGH 261_ SRELE 266_ SVCVV 271_ EAGPG 276_ TCTFD 281_ HRHLY 286_ TKKVT 291_ EDALI 296_ RTVSY 301_ NILAD 306_ TYAQT 311_ EFSRT 316_ VLYPY 321_ CAPYA 326_ LELDY 331_ RQNLI 336_ QKELT 341_ GYNAD 346_ VICLQ 351_ EVDRA 356_ VFSDS 361_ LVPAL 366_ EAFGL 371_ EGVFR 376_ IKQHE 381_ GLATF 386_ YRKSK 391_ FSLLS 396_ QHDIS 401_ FYEAL 406_ ESDPL 411_ HKELL 416_ EKLVL 421_ YPSAQ 426_ EKVLQ 431_ RSSVL 436_ QVSVL 441_ QSTKD 446_ SSKRI 451_ CVANT 456_ HLYWH 461_ PKGGY 466_ IRLIQ 471_ MAVAL 476_ AHIRH 481_ VSCDL 486_ YPGIP 491_ VIFCG 496_ DFNST 501_ PSTGM 506_ YHFVI 511_ NGSIP 516_ EDHED 521_ WASNG 526_ EEERC 531_ NMSLT 536_ HFFKL 541_ KSACG 546_ EPAYT 551_ NYVGG 556_ FHGCL 561_ DYIFI 566_ DLNAL 571_ EVEQV 576_ IPLPS 581_ HEEVT 586_ THQAL 591_ PSVSH 596_ PSDHI 601_ALVCD
1: Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP (PubMed:26055709). Also cleaves 3',5'-phosphodiester bond of oligoadenylates (PubMed:21666256, PubMed:26055709, PubMed:30389976). Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells (PubMed:26055709)