Proline-rich protein 5-like (Protein observed with Rictor-2) (Protor-2)
1_MTRGF 6_ APILP 11_ VEFHK 16_ MGSFR 21_ RPRPR 26_ FMSSP 31_ VLSDL 36_ PRFQA 41_ ARQAL 46_ QLSSS 51_ SAWNS 56_ VQTAV 61_ INVFK 66_ GGGLQ 71_ SNELY 76_ ALNEN 81_ IRRLL 86_ KSELG 91_ SFITD 96_ YFQNQ 101_ LLAKG 106_ LFFVE 111_ EKIKL 116_ CEGEN 121_ RIEVL 126_ AEVWD 131_ HFFTE 136_ TLPTL 141_ QAIFY 146_ PVQGQ 151_ ELTIR 156_ QISLL 161_ GFRDL 166_ VLLKV 171_ KLGDL 176_ LLLAQ 181_ SKLPS 186_ SIVQM 191_ LLILQ 196_ SVHEP 201_ TGPSE 206_ SYLQL 211_ EELVK 216_ QVVSP 221_ FLGIS 226_ GDRSF 231_ SGPTY 236_ TLARR 241_ HSRVR 246_ PKVTV 251_ LNYAS 256_ PITAV 261_ SRPLN 266_ EMVLT 271_ PLTEQ 276_ EGEAY 281_ LEKCG 286_ SVRRH 291_ TVANA 296_ HSDIQ 301_ LLAMA 306_ TMMHS 311_ GLGEE 316_ ASSEN 321_ KCLLL 326_ PPSFP 331_ PPHRQ 336_ CSSEP 341_ NITDN 346_ PDGLE 351_ EGARG 356_ SQEGS 361_ELNCA
1: Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton (PubMed:17461779). Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration (PubMed:22609986). Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF-alpha and GM-CSF, in response to stress (PubMed:21964062). Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress (PubMed:21964062)