Regulator of G-protein signaling 7-binding protein (R7 family-binding protein)
1_MSSAP 6_ NGRKK 11_ RPSRS 16_ TRSSI 21_ FQISK 26_ PPLQS 31_ GDWER 36_ RGSGS 41_ ESAHK 46_ TQRAL 51_ DDCKM 56_ LVQEF 61_ NTQVA 66_ LYREL 71_ VISIG 76_ DVSVS 81_ CPSLR 86_ AEMHK 91_ TRTKG 96_ CEMAR 101_ QAHQK 106_ LAAIS 111_ GPEDG 116_ EIHPE 121_ ICRLY 126_ IQLQC 131_ CLEMY 136_ TTEML 141_ KSICL 146_ LGSLQ 151_ FHRKG 156_ KEPGG 161_ GTKSL 166_ DCKIE 171_ ESAET 176_ PALED 181_ SSSSP 186_ VDSQQ 191_ HSWQV 196_ STDIE 201_ NTERD 206_ MREMK 211_ NLLSK 216_ LRETM 221_ PLPLK 226_ NQDDS 231_ SLLNL 236_ TPYPL 241_ VRRRK 246_ RRFFG 251_LCCLI
1: Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cytoplasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation