Methylcytosine dioxygenase TET2 (EC 1.14.11.n2)
1_MEQDR 6_ TNHVE 11_ GNRLS 16_ PFLIP 21_ SPPIC 26_ QTEPL 31_ ATKLQ 36_ NGSPL 41_ PERAH 46_ PEVNG 51_ DTKWH 56_ SFKSY 61_ YGIPC 66_ MKGSQ 71_ NSRVS 76_ PDFTQ 81_ ESRGY 86_ SKCLQ 91_ NGGIK 96_ RTVSE 101_ PSLSG 106_ LLQIK 111_ KLKQD 116_ QKANG 121_ ERRNF 126_ GVSQE 131_ RNPGE 136_ SSQPN 141_ VSDLS 146_ DKKES 151_ VSSVA 156_ QENAV 161_ KDFTS 166_ FSTHN 171_ CSGPE 176_ NPELQ 181_ ILNEQ 186_ EGKSA 191_ NYHDK 196_ NIVLL 201_ KNKAV 206_ LMPNG 211_ ATVSA 216_ SSVEH 221_ THGEL 226_ LEKTL 231_ SQYYP 236_ DCVSI 241_ AVQKT 246_ TSHIN 251_ AINSQ 256_ ATNEL 261_ SCEIT 266_ HPSHT 271_ SGQIN 276_ SAQTS 281_ NSELP 286_ PKPAA 291_ VVSEA 296_ CDADD 301_ ADNAS 306_ KLAAM 311_ LNTCS 316_ FQKPE 321_ QLQQQ 326_ KSVFE 331_ ICPSP 336_ AENNI 341_ QGTTK 346_ LASGE 351_ EFCSG 356_ SSSNL 361_ QAPGG 366_ SSERY 371_ LKQNE 376_ MNGAY 381_ FKQSS 386_ VFTKD 391_ SFSAT 396_ TTPPP 401_ PSQLL 406_ LSPPP 411_ PLPQV 416_ PQLPS 421_ EGKST 426_ LNGGV 431_ LEEHH 436_ HYPNQ 441_ SNTTL 446_ LREVK 451_ IEGKP 456_ EAPPS 461_ QSPNP 466_ STHVC 471_ SPSPM 476_ LSERP 481_ QNNCV 486_ NRNDI 491_ QTAGT 496_ MTVPL 501_ CSEKT 506_ RPMSE 511_ HLKHN 516_ PPIFG 521_ SSGEL 526_ QDNCQ 531_ QLMRN 536_ KEQEI 541_ LKGRD 546_ KEQTR 551_ DLVPP 556_ TQHYL 561_ KPGWI 566_ ELKAP 571_ RFHQA 576_ ESHLK 581_ RNEAS 586_ LPSIL 591_ QYQPN 596_ LSNQM 601_ TSKQY 606_ TGNSN 611_ MPGGL 616_ PRQAY 621_ TQKTT 626_ QLEHK 631_ SQMYQ 636_ VEMNQ 641_ GQSQG 646_ TVDQH 651_ LQFQK 656_ PSHQV 661_ HFSKT 666_ DHLPK 671_ AHVQS 676_ LCGTR 681_ FHFQQ 686_ RADSQ 691_ TEKLM 696_ SPVLK 701_ QHLNQ 706_ QASET 711_ EPFSN 716_ SHLLQ 721_ HKPHK 726_ QAAQT 731_ QPSQS 736_ SHLPQ 741_ NQQQQ 746_ QKLQI 751_ KNKEE 756_ ILQTF 761_ PHPQS 766_ NNDQQ 771_ REGSF 776_ FGQTK 781_ VEECF 786_ HGENQ 791_ YSKSS 796_ EFETH 801_ NVQMG 806_ LEEVQ 811_ NINRR 816_ NSPYS 821_ QTMKS 826_ SACKI 831_ QVSCS 836_ NNTHL 841_ VSENK 846_ EQTTH 851_ PELFA 856_ GNKTQ 861_ NLHHM 866_ QYFPN 871_ NVIPK 876_ QDLLH 881_ RCFQE 886_ QEQKS 891_ QQASV 896_ LQGYK 901_ NRNQD 906_ MSGQQ 911_ AAQLA 916_ QQRYL 921_ IHNHA 926_ NVFPV 931_ PDQGG 936_ SHTQT 941_ PPQKD 946_ TQKHA 951_ ALRWH 956_ LLQKQ 961_ EQQQT 966_ QQPQT 971_ ESCHS 976_ QMHRP 981_ IKVEP 986_ GCKPH 991_ ACMHT 996_ APPEN 1001_ KTWKK 1006_ VTKQE 1011_ NPPAS 1016_ CDNVQ 1021_ QKSII 1026_ ETMEQ 1031_ HLKQF 1036_ HAKSL 1041_ FDHKA 1046_ LTLKS 1051_ QKQVK 1056_ VEMSG 1061_ PVTVL 1066_ TRQTT 1071_ AAELD 1076_ SHTPA 1081_ LEQQT 1086_ TSSEK 1091_ TPTKR 1096_ TAASV 1101_ LNNFI 1106_ ESPSK 1111_ LLDTP 1116_ IKNLL 1121_ DTPVK 1126_ TQYDF 1131_ PSCRC 1136_ VEQII 1141_ EKDEG 1146_ PFYTH 1151_ LGAGP 1156_ NVAAI 1161_ REIME 1166_ ERFGQ 1171_ KGKAI 1176_ RIERV 1181_ IYTGK 1186_ EGKSS 1191_ QGCPI 1196_ AKWVV 1201_ RRSSS 1206_ EEKLL 1211_ CLVRE 1216_ RAGHT 1221_ CEAAV 1226_ IVILI 1231_ LVWEG 1236_ IPLSL 1241_ ADKLY 1246_ SELTE 1251_ TLRKY 1256_ GTLTN 1261_ RRCAL 1266_ NEERT 1271_ CACQG 1276_ LDPET 1281_ CGASF 1286_ SFGCS 1291_ WSMYY 1296_ NGCKF 1301_ ARSKI 1306_ PRKFK 1311_ LLGDD 1316_ PKEEE 1321_ KLESH 1326_ LQNLS 1331_ TLMAP 1336_ TYKKL 1341_ APDAY 1346_ NNQIE 1351_ YEHRA 1356_ PECRL 1361_ GLKEG 1366_ RPFSG 1371_ VTACL 1376_ DFCAH 1381_ AHRDL 1386_ HNMQN 1391_ GSTLV 1396_ CTLTR 1401_ EDNRE 1406_ FGGKP 1411_ EDEQL 1416_ HVLPL 1421_ YKVSD 1426_ VDEFG 1431_ SVEAQ 1436_ EEKKR 1441_ SGAIQ 1446_ VLSSF 1451_ RRKVR 1456_ MLAEP 1461_ VKTCR 1466_ QRKLE 1471_ AKKAA 1476_ AEKLS 1481_ SLENS 1486_ SNKNE 1491_ KEKSA 1496_ PSRTK 1501_ QTENA 1506_ SQAKQ 1511_ LAELL 1516_ RLSGP 1521_ VMQQS 1526_ QQPQP 1531_ LQKQP 1536_ PQPQQ 1541_ QQRPQ 1546_ QQQPH 1551_ HPQTE 1556_ SVNSY 1561_ SASGS 1566_ TNPYM 1571_ RRPNP 1576_ VSPYP 1581_ NSSHT 1586_ SDIYG 1591_ STSPM 1596_ NFYST 1601_ SSQAA 1606_ GSYLN 1611_ SSNPM 1616_ NPYPG 1621_ LLNQN 1626_ TQYPS 1631_ YQCNG 1636_ NLSVD 1641_ NCSPY 1646_ LGSYS 1651_ PQSQP 1656_ MDLYR 1661_ YPSQD 1666_ PLSKL 1671_ SLPPI 1676_ HTLYQ 1681_ PRFGN 1686_ SQSFT 1691_ SKYLG 1696_ YGNQN 1701_ MQGDG 1706_ FSSCT 1711_ IRPNV 1716_ HHVGK 1721_ LPPYP 1726_ THEMD 1731_ GHFMG 1736_ ATSRL 1741_ PPNLS 1746_ NPNMD 1751_ YKNGE 1756_ HHSPS 1761_ HIIHN 1766_ YSAAP 1771_ GMFNS 1776_ SLHAL 1781_ HLQNK 1786_ ENDML 1791_ SHTAN 1796_ GLSKM 1801_ LPALN 1806_ HDRTA 1811_ CVQGG 1816_ LHKLS 1821_ DANGQ 1826_ EKQPL 1831_ ALVQG 1836_ VASGA 1841_ EDNDE 1846_ VWSDS 1851_ EQSFL 1856_ DPDIG 1861_ GVAVA 1866_ PTHGS 1871_ ILIEC 1876_ AKREL 1881_ HATTP 1886_ LKNPN 1891_ RNHPT 1896_ RISLV 1901_ FYQHK 1906_ SMNEP 1911_ KHGLA 1916_ LWEAK 1921_ MAEKA 1926_ REKEE 1931_ ECEKY 1936_ GPDYV 1941_ PQKSH 1946_ GKKVK 1951_ REPAE 1956_ PHETS 1961_ EPTYL 1966_ RFIKS 1971_ LAERT 1976_ MSVTT 1981_ DSTVT 1986_ TSPYA 1991_ FTRVT 1996_GPYNR
1: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT