Volume-regulated anion channel subunit LRRC8E (Leucine-rich repeat-containing protein 8E)
1_MIPVA 6_ EFKQF 11_ TEQQP 16_ AFKVL 21_ KPWWD 26_ VLAEY 31_ LTVAM 36_ LMIGV 41_ FGCTL 46_ QVTQD 51_ KIICL 56_ PNHEL 61_ QENLS 66_ EAPCQ 71_ QLLPR 76_ GIPEQ 81_ IGALQ 86_ EVKGL 91_ KNNLD 96_ LQQYS 101_ FINQL 106_ CYETA 111_ LHWYA 116_ KYFPY 121_ LVVIH 126_ TLIFM 131_ VCTSF 136_ WFKFP 141_ GTSSK 146_ IEHFI 151_ SILGK 156_ CFDSP 161_ WTTRA 166_ LSEVS 171_ GENQK 176_ GPAAT 181_ ERAAA 186_ TIVAM 191_ AGTGP 196_ GKAGE 201_ GEKEK 206_ VLAEP 211_ EKVVT 216_ EPPVV 221_ TLLDK 226_ KEGEQ 231_ AKALF 236_ EKVKK 241_ FRMHV 246_ EEGDI 251_ LYTMY 256_ IRQTV 261_ LKVCK 266_ FLAIL 271_ VYNLV 276_ YVEKI 281_ SFLVA 286_ CRVET 291_ SEVTG 296_ YASFC 301_ CNHTK 306_ AHLFS 311_ KLAFC 316_ YISFV 321_ CIYGL 326_ TCIYT 331_ LYWLF 336_ HRPLK 341_ EYSFR 346_ SVREE 351_ TGMGD 356_ IPDVK 361_ NDFAF 366_ MLHLI 371_ DQYDS 376_ LYSKR 381_ FAVFL 386_ SEVSE 391_ SRLKQ 396_ LNLNH 401_ EWTPE 406_ KLRQK 411_ LQRNA 416_ AGRLE 421_ LALCM 426_ LPGLP 431_ DTVFE 436_ LSEVE 441_ SLRLE 446_ AICDI 451_ TFPPG 456_ LSQLV 461_ HLQEL 466_ SLLHS 471_ PARLP 476_ FSLQV 481_ FLRDH 486_ LKVMR 491_ VKCEE 496_ LREVP 501_ LWVFG 506_ LRGLE 511_ ELHLE 516_ GLFPQ 521_ ELARA 526_ ATLES 531_ LRELK 536_ QLKVL 541_ SLRSN 546_ AGKVP 551_ ASVTD 556_ VAGHL 561_ QRLSL 566_ HNDGA 571_ RLVAL 576_ NSLKK 581_ LAALR 586_ ELELV 591_ ACGLE 596_ RIPHA 601_ VFSLG 606_ ALQEL 611_ DLKDN 616_ HLRSI 621_ EEILS 626_ FQHCR 631_ KLVTL 636_ RLWHN 641_ QIAYV 646_ PEHVR 651_ KLRSL 656_ EQLYL 661_ SYNKL 666_ ETLPS 671_ QLGLC 676_ SGLRL 681_ LDVSH 686_ NGLHS 691_ LPPEV 696_ GLLQN 701_ LQHLA 706_ LSYNA 711_ LEALP 716_ EELFF 721_ CRKLR 726_ TLLLG 731_ DNQLS 736_ QLSPH 741_ VGALR 746_ ALSRL 751_ ELKGN 756_ RLEAL 761_ PEELG 766_ NCGGL 771_ KKAGL 776_ LVEDT 781_ LYQGL 786_ PAEVR 791_DKMEE
1: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658). Mediates efflux of amino acids, such as aspartate, in response to osmotic stress (PubMed:28193731). The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PubMed:33171122). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731). Also plays a role in lysosome homeostasis by forming functional lysosomal VRAC channels in response to low cytoplasmic ionic strength condition: lysosomal VRAC channels are necessary for the formation of large lysosome-derived vacuoles, which store and then expel excess water to maintain cytosolic water homeostasis (PubMed:33139539)