MFS-type transporter SLC18B1 (Solute carrier family 18 member B1)
1_MEALG 6_ DLEGP 11_ RAPGG 16_ DDPAG 21_ SAGET 26_ PGWLS 31_ REQVF 36_ VLISA 41_ ASVNL 46_ GSMMC 51_ YSILG 56_ PFFPK 61_ EAEKK 66_ GASNT 71_ IIGMI 76_ FGCFA 81_ LFELL 86_ ASLVF 91_ GNYLV 96_ HIGAK 101_ FMFVA 106_ GMFVS 111_ GGVTI 116_ LFGVL 121_ DRVPD 126_ GPVFI 131_ AMCFL 136_ VRVMD 141_ AVSFA 146_ AAMTA 151_ SSSIL 156_ AKAFP 161_ NNVAT 166_ VLGSL 171_ ETFSG 176_ LGLIL 181_ GPPVG 186_ GFLYQ 191_ SFGYE 196_ VPFIV 201_ LGCVV 206_ LLMVP 211_ LNMYI 216_ LPNYE 221_ SDPGE 226_ HSFWK 231_ LIALP 236_ KVGLI 241_ AFVIN 246_ SLSSC 251_ FGFLD 256_ PTLSL 261_ FVLEK 266_ FNLPA 271_ GYVGL 276_ VFLGM 281_ ALSYA 286_ ISSPL 291_ FGLLS 296_ DKRPP 301_ LRKWL 306_ LVFGN 311_ LITAG 316_ CYMLL 321_ GPVPI 326_ LHIKS 331_ QLWLL 336_ VLILV 341_ VSGLS 346_ AGMSI 351_ IPTFP 356_ EILSC 361_ AHENG 366_ FEEGL 371_ STLGL 376_ VSGLF 381_ SAMWS 386_ IGAFM 391_ GPTLG 396_ GFLYE 401_ KIGFE 406_ WAAAI 411_ QGLWA 416_ LISGL 421_ AMGLF 426_ YLLEY 431_ SRRKR 436_ SKSQN 441_ ILSTE 446_ EERTT 451_LLPNE
1: Proton-coupled polyamine antiporter involved in the translocation of polyamines from cytosol into secretory vesicles prior to their release via exocytosis. Uses the electrochemical proton gradient generated by a V-type proton-pumping ATPase to couple the efflux of protons with the uptake of a polyamine molecule (PubMed:25355561). Facilitates vesicular storage of spermine and spermidine in astrocytes with an impact on glutamatergic neuronal transmission and memory formation (By similarity) (PubMed:25355561). Upon antigen stimulation, regulates polyamine accumulation and release in mast cell secretory granules, which in turn potentiates mast cell degranulation and histamine secretion (By similarity)