Homeobox-containing protein 1 (Homeobox telomere-binding protein 1) (Telomere-associated homeobox-containing protein 1)
1_MLSSF 6_ PVVLL 11_ ETMSH 16_ YTDEP 21_ RFTIE 26_ QIDLL 31_ QRLRR 36_ TGMTK 41_ HEILH 46_ ALETL 51_ DRLDQ 56_ EHSDK 61_ FGRRS 66_ SYGGS 71_ SYGNS 76_ TNNVP 81_ ASSST 86_ ATAST 91_ QTQHS 96_ GMSPS 101_ PSNSY 106_ DTSPQ 111_ PCTTN 116_ QNGRE 121_ NNERL 126_ STSNG 131_ KMSPT 136_ RYHAN 141_ SMGQR 146_ SYSFE 151_ ASEED 156_ LDVDD 161_ KVEEL 166_ MRRDS 171_ SVIKE 176_ EIKAF 181_ LANRR 186_ ISQAV 191_ VAQVT 196_ GISQS 201_ RISHW 206_ LLQQG 211_ SDLSE 216_ QKKRA 221_ FYRWY 226_ QLEKT 231_ NPGAT 236_ LSMRP 241_ APIPI 246_ EDPEW 251_ RQTPP 256_ PVSAT 261_ SGTFR 266_ LRRGS 271_ RFTWR 276_ KECLA 281_ VMESY 286_ FNENQ 291_ YPDEA 296_ KREEI 301_ ANACN 306_ AVIQK 311_ PGKKL 316_ SDLER 321_ VTSLK 326_ VYNWF 331_ ANRRK 336_ EIKRR 341_ ANIEA 346_ AILES 351_ HGIDV 356_ QSPGG 361_ HSNSD 366_ DVDGN 371_ DYSEQ 376_ DDSTS 381_ HSDHQ 386_ DPISL 391_ AVEMA 396_ AVNHT 401_ ILALA 406_ RQGAN 411_EIKTE
1: Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA (PubMed:23685356, PubMed:23813958). Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation (PubMed:23685356). Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres (By similarity). Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) (PubMed:23813958). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination (PubMed:23813958). Might also be involved in the DNA damage response at telomeres (PubMed:23813958)