PWWP domain-containing protein 2B
1_MEPRA 6_ GCRLP 11_ VRVEQ 16_ VVNGA 21_ LVVTV 26_ SCGER 31_ SFAGI 36_ LLDCT 41_ KKSGL 46_ FGLPP 51_ LAPLP 56_ QVDES 61_ PVNDS 66_ HGRAP 71_ EEGDA 76_ EVMQL 81_ GSSSP 86_ PPARG 91_ VQPPE 96_ TTRPE 101_ PPPPL 106_ VPPLP 111_ AGSLP 116_ PYPPY 121_ FEGAP 126_ FPHPL 131_ WLRDT 136_ YKLWV 141_ PQPPP 146_ RTIKR 151_ TRRRL 156_ SRNRD 161_ PGRLI 166_ LSTIR 171_ LRPRQ 176_ VLCEK 181_ CKSTL 186_ SPPEA 191_ SPGPP 196_ AAPRA 201_ RRRLG 206_ SGPDR 211_ ELRKP 216_ EEPEN 221_ GEPTA 226_ AATAR 231_ RSKRE 236_ RREED 241_ RAPAE 246_ QVPRS 251_ PVIKI 256_ SYSTP 261_ QGKGE 266_ VVKIP 271_ SRVHG 276_ SLEPF 281_ RPQQA 286_ PQDDG 291_ SQDPE 296_ VLDRE 301_ SRDRP 306_ SCAPS 311_ ASIPK 316_ LKLTR 321_ PVPAG 326_ ADLPP 331_ PKIRL 336_ KPHRL 341_ GDSEH 346_ EPVYR 351_ AELVG 356_ ELNGY 361_ LRDSS 366_ PAPCA 371_ DGPAG 376_ GLADL 381_ SSGSS 386_ GEDDD 391_ FKSCP 396_ QGPQG 401_ REGLA 406_ FLVSC 411_ PEGRA 416_ DCASE 421_ SACSS 426_ DSLDE 431_ ARSSG 436_ SEGTP 441_ ADTGD 446_ LSPGH 451_ GASAP 456_ SVSRE 461_ ARQTV 466_ PPLTV 471_ RLHTQ 476_ SVSEC 481_ ITEDG 486_ RTVAV 491_ GDIVW 496_ GKIHG 501_ FPWWP 506_ ARVLD 511_ ISLGQ 516_ KEDGE 521_ PSWRE 526_ AKVSW 531_ FGSPT 536_ TSFLS 541_ ISKLS 546_ PFSEF 551_ FKLRF 556_ NRKKK 561_ GMYRK 566_ AITEA 571_ ANAAR 576_ HVAPE 581_IRELL
1: Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260). Plays a role in facilitating transcriptional elongation through regulation of histone acetylation (By similarity). Negatively regulates brown adipocyte thermogenesis by interacting with and stabilizing HDAC1 at the UCP1 gene promoter, thereby promoting histone deacetylation at the promoter leading to the repression of UCP1 expression (By similarity)