Calcium-binding mitochondrial carrier protein SCaMC-1 (Mitochondrial ATP-Mg/Pi carrier protein 1) (Mitochondrial Ca(2+)-dependent solute carrier protein 1) (Small calcium-binding mitochondrial carrier protein 1) (Solute carrier family 25 member 24)
1_MLRWL 6_ RDFVL 11_ PTAAC 16_ QDAEQ 21_ PTRYE 26_ TLFQA 31_ LDRNG 36_ DGVVD 41_ IGELQ 46_ EGLRN 51_ LGIPL 56_ GQDAE 61_ EKIFT 66_ TGDVN 71_ KDGKL 76_ DFEEF 81_ MKYLK 86_ DHEKK 91_ MKLAF 96_ KSLDK 101_ NNDGK 106_ IEASE 111_ IVQSL 116_ QTLGL 121_ TISEQ 126_ QAELI 131_ LQSID 136_ VDGTM 141_ TVDWN 146_ EWRDY 151_ FLFNP 156_ VTDIE 161_ EIIRF 166_ WKHST 171_ GIDIG 176_ DSLTI 181_ PDEFT 186_ EDEKK 191_ SGQWW 196_ RQLLA 201_ GGIAG 206_ AVSRT 211_ STAPL 216_ DRLKI 221_ MMQVH 226_ GSKSD 231_ KMNIF 236_ GGFRQ 241_ MVKEG 246_ GIRSL 251_ WRGNG 256_ TNVIK 261_ IAPET 266_ AVKFW 271_ AYEQY 276_ KKLLT 281_ EEGQK 286_ IGTFE 291_ RFISG 296_ SMAGA 301_ TAQTF 306_ IYPME 311_ VMKTR 316_ LAVGK 321_ TGQYS 326_ GIYDC 331_ AKKIL 336_ KHEGL 341_ GAFYK 346_ GYVPN 351_ LLGII 356_ PYAGI 361_ DLAVY 366_ ELLKS 371_ YWLDN 376_ FAKDS 381_ VNPGV 386_ MVLLG 391_ CGALS 396_ STCGQ 401_ LASYP 406_ LALVR 411_ TRMQA 416_ QAMLE 421_ GSPQL 426_ NMVGL 431_ FRRII 436_ SKEGI 441_ PGLYR 446_ GITPN 451_ FMKVL 456_ PAVGI 461_ SYVVY 466_ ENMKQ 471_TLGVT
1: Electroneutral antiporter that mediates the transport of adenyl nucleotides through the inner mitochondrial membrane. Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it also acts as a broad specificity adenyl nucleotide antiporter. By regulating the mitochondrial matrix adenyl nucleotide pool could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide-dependent metabolic pathways (PubMed:15123600, PubMed:22015608). In vitro, a low activity is also observed with guanyl and pyrimidine nucleotides (PubMed:15123600). May play a role in protecting cells against oxidative stress-induced cell death, by buffering calcium levels in the mitochondrial matrix through the formation of calcium-phosphate precipitates (PubMed:22015608, PubMed:29100093)