All-trans-retinol 13,14-reductase (EC 1.3.99.23) (All-trans-13,14-dihydroretinol saturase) (RetSat) (PPAR-alpha-regulated and starvation-induced gene protein)
1_MWLPL 6_ VLLLA 11_ VLLLA 16_ VLCKV 21_ YLGLF 26_ SGSSP 31_ NPFSE 36_ DVKRP 41_ PAPLV 46_ TDKEA 51_ RKKVL 56_ KQAFS 61_ ANQVP 66_ EKLDV 71_ VVIGS 76_ GFGGL 81_ AAAAI 86_ LAKAG 91_ KRVLV 96_ LEQHT 101_ KAGGC 106_ CHTFG 111_ KNGLE 116_ FDTGI 121_ HYIGR 126_ MEEGS 131_ IGRFI 136_ LDQIT 141_ EGQLD 146_ WAPLS 151_ SPFDI 156_ MVLEG 161_ PNGRK 166_ EYPMY 171_ SGEKA 176_ YIQGL 181_ KEKFP 186_ QEEAI 191_ IDKYI 196_ KLVKV 201_ VSSGA 206_ PHAIL 211_ LKFLP 216_ LPVVQ 221_ LLDRC 226_ GLLTR 231_ FSPFL 236_ QASTQ 241_ SLAEV 246_ LQQLG 251_ ASSEL 256_ QAVLS 261_ YIFPT 266_ YGVTP 271_ NHSAF 276_ SMHAL 281_ LVNHY 286_ MKGGF 291_ YPRGG 296_ SSEIA 301_ FHTIP 306_ VIQRA 311_ GGAVL 316_ TKATV 321_ QSVLL 326_ DSAGK 331_ ACGVS 336_ VKKGH 341_ ELVNI 346_ YCPIV 351_ VSNAG 356_ LFNTY 361_ EHLLP 366_ GNARC 371_ LPGVK 376_ QQLGT 381_ VRPGL 386_ GMTSV 391_ FICLR 396_ GTKED 401_ LHLPS 406_ TNYYV 411_ YYDTD 416_ MDQAM 421_ ERYVS 426_ MPREE 431_ AAEHI 436_ PLLFF 441_ AFPSA 446_ KDPTW 451_ EDRFP 456_ GRSTM 461_ IMLIP 466_ TAYEW 471_ FEEWQ 476_ AELKG 481_ KRGSD 486_ YETFK 491_ NSFVE 496_ ASMSV 501_ VLKLF 506_ PQLEG 511_ KVESV 516_ TAGSP 521_ LTNQF 526_ YLAAP 531_ RGACY 536_ GADHD 541_ LGRLH 546_ PCVMA 551_ SLRAQ 556_ SPIPN 561_ LYLTG 566_ QDIFT 571_ CGLVG 576_ ALQGA 581_ LLCSS 586_ AILKR 591_ NLYSD 596_ LKNLD 601_SRIRA
1: Catalyzes the saturation of all-trans-retinol to all-trans-13,14-dihydroretinol. Does not exhibit any activity toward all-trans-retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers. May play a role in the metabolism of vitamin A. Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP. May play a role in adipocyte differentiation