Major facilitator superfamily domain-containing protein 12
1_MGPGP 6_ PAAGA 11_ APSPR 16_ PLSLV 21_ ARLSY 26_ AVGHF 31_ LNDLC 36_ ASMWF 41_ TYLLL 46_ YLHSV 51_ RAYSS 56_ RGAGL 61_ LLLLG 66_ QVADG 71_ LCTPL 76_ VGYEA 81_ DRAAS 86_ CCARY 91_ GPRKA 96_ WHLVG 101_ TVCVL 106_ LSFPF 111_ IFSPC 116_ LGCGA 121_ ATPEW 126_ AALLY 131_ YGPFI 136_ VIFQF 141_ GWAST 146_ QISHL 151_ SLIPE 156_ LVTND 161_ HEKVE 166_ LTALR 171_ YAFTV 176_ VANIT 181_ VYGAA 186_ WLLLH 191_ LQGSS 196_ RVEPT 201_ QDISI 206_ SDQLG 211_ GQDVP 216_ VFRNL 221_ SLLVV 226_ GVGAV 231_ FSLLF 236_ HLGTR 241_ ERRRP 246_ HAEEP 251_ GEHTP 256_ LLAPA 261_ TAQPL 266_ LLWKH 271_ WLREP 276_ AFYQV 281_ GILYM 286_ TTRLI 291_ VNLSQ 296_ TYMAM 301_ YLTYS 306_ LHLPK 311_ KFIAT 316_ IPLVM 321_ YLSGF 326_ LSSFL 331_ MKPIN 336_ KCIGR 341_ NMTYF 346_ SGLLV 351_ ILAFA 356_ AWVAL 361_ AEGLG 366_ VAVYA 371_ AAVLL 376_ GAGCA 381_ TILVT 386_ SLAMT 391_ ADLIG 396_ PHTNS 401_ GAFVY 406_ GSMSF 411_ LDKVA 416_ NGLAV 421_ MAIQS 426_ LHPCP 431_ SELCC 436_ RACVS 441_ FYHWA 446_ MVAVT 451_ GGVGV 456_ AAALC 461_ LCSLL 466_ LWPTR 471_LRRWD
1: Transporter that mediates the import of cysteine into melanosomes, thereby regulating skin pigmentation (PubMed:33208952, PubMed:37751742). In melanosomes, cysteine import is required both for normal levels of cystine, the oxidized dimer of cysteine, and provide cysteine for the production of the cysteinyldopas used in pheomelanin synthesis, thereby regulating skin pigmentation (PubMed:33208952). Also catalyzes import of cysteine into lysosomes in non-pigmented cells, regulating lysosomal cystine and cysteine storage, which is essnetial for redox homeostasis (PubMed:33208952, PubMed:37751742)