Epithelial splicing regulatory protein 1 (RNA-binding motif protein 35A) (RNA-binding protein 35A)
1_MTASP 6_ DYLVV 11_ LFGIT 16_ AGATG 21_ AKLGS 26_ DEKEL 31_ ILLFW 36_ KVVDL 41_ ANKKV 46_ GQLHE 51_ VLVRP 56_ DQLEL 61_ TEDCK 66_ EETKI 71_ DVESL 76_ SSASQ 81_ LDQAL 86_ RQFNQ 91_ SVSNE 96_ LNIGV 101_ GTSFC 106_ LCTDG 111_ QLHVR 116_ QILHP 121_ EASKK 126_ NVLLP 131_ ECFYS 136_ FFDLR 141_ KEFKK 146_ CCPGS 151_ PDIDK 156_ LDVAT 161_ MTEYL 166_ NFEKS 171_ SSVSR 176_ YGASQ 181_ VEDMG 186_ NIILA 191_ MISEP 196_ YNHRF 201_ SDPER 206_ VNYKF 211_ ESGTC 216_ SKMEL 221_ IDDNT 226_ VVRAR 231_ GLPWQ 236_ SSDQD 241_ IARFF 246_ KGLNI 251_ AKGGA 256_ ALCLN 261_ AQGRR 266_ NGEAL 271_ VRFVS 276_ EEHRD 281_ LALQR 286_ HKHHM 291_ GTRYI 296_ EVYKA 301_ TGEDF 306_ LKIAG 311_ GTSNE 316_ VAQFL 321_ SKENQ 326_ VIVRM 331_ RGLPF 336_ TATAE 341_ EVVAF 346_ FGQHC 351_ PITGG 356_ KEGIL 361_ FVTYP 366_ DGRPT 371_ GDAFV 376_ LFACE 381_ EYAQN 386_ ALRKH 391_ KDLLG 396_ KRYIE 401_ LFRST 406_ AAEVQ 411_ QVLNR 416_ FSSAP 421_ LIPLP 426_ TPPII 431_ PVLPQ 436_ QFVPP 441_ TNVRD 446_ CIRLR 451_ GLPYA 456_ ATIED 461_ ILDFL 466_ GEFAT 471_ DIRTH 476_ GVHMV 481_ LNHQG 486_ RPSGD 491_ AFIQM 496_ KSADR 501_ AFMAA 506_ QKCHK 511_ KNMKD 516_ RYVEV 521_ FQCSA 526_ EEMNF 531_ VLMGG 536_ TLNRN 541_ GLSPP 546_ PCKLP 551_ CLSPP 556_ SYTFP 561_ APAAV 566_ IPTEA 571_ AIYQP 576_ SVILN 581_ PRALQ 586_ PSTAY 591_ YPAGT 596_ QLFMN 601_ YTAYY 606_ PSPPG 611_ SPNSL 616_ GYFPT 621_ AANLS 626_ GVPPQ 631_ PGTVV 636_ RMQGL 641_ AYNTG 646_ VKEIL 651_ NFFQG 656_ YQYAT 661_ EDGLI 666_ HTNDQ 671_ ARTLP 676_KEWVC
1: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (PubMed:19285943). Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium (By similarity)