TELO2-interacting protein 2
1_MELDS 6_ ALEAP 11_ SQEDS 16_ NLSEE 21_ LSHSA 26_ FGQAF 31_ SKILH 36_ CLARP 41_ EARRG 46_ NVKDA 51_ VLKDL 56_ GDLIE 61_ ATEFD 66_ RLFEG 71_ TGARL 76_ RGMPE 81_ TLGQV 86_ AKALE 91_ KYAAP 96_ SKEEE 101_ GGGDG 106_ HSEAA 111_ EKAAQ 116_ VGLLF 121_ LKLLG 126_ KVETA 131_ KNSLV 136_ GPAWQ 141_ TGLHH 146_ LAGPV 151_ YIFAI 156_ THSLE 161_ QPWTT 166_ PRSRE 171_ VAREV 176_ LTSLL 181_ QVTEC 186_ GSVAG 191_ FLHGE 196_ NEDEK 201_ GRLSV 206_ ILGLL 211_ KPDLY 216_ KESWK 221_ NNPAI 226_ KHVFS 231_ WTLQQ 236_ VTRPW 241_ LSQHL 246_ ERVLP 251_ ASLVI 256_ SDDYQ 261_ TENKI 266_ LGVHC 271_ LHHIV 276_ LNVPA 281_ ADLLQ 286_ YNRAQ 291_ VLYHA 296_ ISNHL 301_ YTPEH 306_ HLIQA 311_ VLLCL 316_ LDLFP 321_ ILEKT 326_ LHWKG 331_ DGARP 336_ TTHCD 341_ EVLRL 346_ ILTHM 351_ EPEHR 356_ LLLRR 361_ TYARN 366_ LPAFV 371_ NRLGI 376_ LTVRH 381_ LKRLE 386_ RVIIG 391_ YLEVY 396_ DGPEE 401_ EARLK 406_ ILETL 411_ KLLMQ 416_ HTWPR 421_ VSCRL 426_ VVLLK 431_ ALLKL 436_ ICDVA 441_ RDPNL 446_ TPESV 451_ KSALL 456_ QEATD 461_ CLILL 466_ DRCSQ 471_ GRVKG 476_ LLAKI 481_ PQSCE 486_ DRKVV 491_ NYIRK 496_ VQQVS 501_EGAPY
1: Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs