Histone H3.3C (Histone H3.5)
1_MARTK 6_ QTARK 11_ STGGK 16_ APRKQ 21_ LATKA 26_ ARKST 31_ PSTCG 36_ VKPHR 41_ YRPGT 46_ VALRE 51_ IRRYQ 56_ KSTEL 61_ LIRKL 66_ PFQRL 71_ VREIA 76_ QDFNT 81_ DLRFQ 86_ SAAVG 91_ ALQEA 96_ SEAYL 101_ VGLLE 106_ DTNLC 111_ AIHAK 116_ RVTIM 121_ PKDIQ 126_LARRI
1: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Hominid-specific H3.5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes