Zinc transporter 6 (ZnT-6) (Solute carrier family 30 member 6)
1_MGTIH 6_ LFRKP 11_ QRSFF 16_ GKLLR 21_ EFRLV 26_ AADRR 31_ SWKIL 36_ LFGVI 41_ NLICT 46_ GFLLM 51_ WCSST 56_ NSIAL 61_ TAYTY 66_ LTIFD 71_ LFSLM 76_ TCLIS 81_ YWVTL 86_ RKPSP 91_ VYSFG 96_ FERLE 101_ VLAVF 106_ ASTVL 111_ AQLGA 116_ LFILK 121_ ESAER 126_ FLEQP 131_ EIHTG 136_ RLLVG 141_ TFVAL 146_ CFNLF 151_ TMLSI 156_ RNKPF 161_ AYVSE 166_ AASTS 171_ WLQEH 176_ VADLS 181_ RSLCG 186_ IIPGL 191_ SSIFL 196_ PRMNP 201_ FVLID 206_ LAGAF 211_ ALCIT 216_ YMLIE 221_ INNYF 226_ AVDTA 231_ SAIAI 236_ ALMTF 241_ GTMYP 246_ MSVYS 251_ GKVLL 256_ QTTPP 261_ HVIGQ 266_ LDKLI 271_ REVST 276_ LDGVL 281_ EVRNE 286_ HFWTL 291_ GFGSL 296_ AGSVH 301_ VRIRR 306_ DANEQ 311_ MVLAH 316_ VTNRL 321_ YTLVS 326_ TLTVQ 331_ IFKDD 336_ WIRPA 341_ LLSGP 346_ VAANV 351_ LNFSD 356_ HHVIP 361_ MPLLK 366_ GTDDL 371_ NPVTS 376_ TPAKP 381_ SSPPP 386_ EFSFN 391_ TPGKN 396_ VNPVI 401_ LLNTQ 406_ TRPYG 411_ FGLNH 416_ GHTPY 421_ SSMLN 426_ QGLGV 431_ PGIGA 436_ TQGLR 441_ TGFTN 446_ IPSRY 451_ GTNNR 456_IGQPR
1: Has probably no intrinsic transporter activity but together with SLC30A5 forms a functional zinc ion:proton antiporter heterodimer, mediating zinc entry into the lumen of organelles along the secretory pathway (PubMed:15994300, PubMed:19366695, PubMed:19759014). As part of that zinc ion:proton antiporter, contributes to zinc ion homeostasis within the early secretory pathway and regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis (PubMed:15994300, PubMed:19759014, PubMed:35525268)