Caveolae-associated protein 1 (Cavin-1) (Polymerase I and transcript release factor)
1_MEDPT 6_ LYIVE 11_ RPLPG 16_ YPDAE 21_ APEPS 26_ SAGAQ 31_ AAEEP 36_ SGAGS 41_ EELIK 46_ SDQVN 51_ GVLVL 56_ SLLDK 61_ IIGAV 66_ DQIQL 71_ TQAQL 76_ EERQA 81_ EMEGA 86_ VQSIQ 91_ GELSK 96_ LGKAH 101_ ATTSN 106_ TVSKL 111_ LEKVR 116_ KVSVN 121_ VKTVR 126_ GSLER 131_ QAGQI 136_ KKLEV 141_ NEAEL 146_ LRRRN 151_ FKVMI 156_ YQDEV 161_ KLPAK 166_ LSISK 171_ SLKES 176_ EALPE 181_ KEGEE 186_ LGEGE 191_ RPEED 196_ AAALE 201_ LSSDE 206_ AVEVE 211_ EVIEE 216_ SRAER 221_ IKRSG 226_ LRRVD 231_ DFKKA 236_ FSKEK 241_ MEKTK 246_ VRTRE 251_ NLEKT 256_ RLKTK 261_ ENLEK 266_ TRHTL 271_ EKRMN 276_ KLGTR 281_ LVPAE 286_ RREKL 291_ KTSRD 296_ KLRKS 301_ FTPDH 306_ VVYAR 311_ SKTAV 316_ YKVPP 321_ FTFHV 326_ KKIRE 331_ GQVEV 336_ LKATE 341_ MVEVG 346_ ADDDE 351_ GGAER 356_ GEAGD 361_ LRRGS 366_ SPDVH 371_ ALLEI 376_ TEESD 381_AVLVD
1: Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18056712, PubMed:18191225, PubMed:19726876). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (By similarity) (PubMed:18056712, PubMed:18191225, PubMed:19726876). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (By similarity)