Zinc finger CCHC domain-containing protein 8 (TRAMP-like complex RNA-binding factor ZCCHC8)
1_MAAEV 6_ YFGDL 11_ ELFEP 16_ FDHPE 21_ ESIPK 26_ PVHTR 31_ FKDDD 36_ GDEED 41_ ENGVG 46_ DAELR 51_ ERLRQ 56_ CEETI 61_ EQLRA 66_ ENQEL 71_ KRKLN 76_ ILTRP 81_ SGILV 86_ NDTKL 91_ DGPIL 96_ QILFM 101_ NNAIS 106_ KQYHQ 111_ EIEEF 116_ VSNLV 121_ KRFEE 126_ QQKND 131_ VEKTS 136_ FNLLP 141_ QPSSI 146_ VLEED 151_ HKVEE 156_ SCAIK 161_ NNKEA 166_ FSVVG 171_ SVLYF 176_ TNFCL 181_ DKLGQ 186_ PLLNE 191_ NPQLS 196_ EGWEI 201_ PKYHQ 206_ VFSHI 211_ VSLEG 216_ QEIQV 221_ KAKRP 226_ KPHCF 231_ NCGSE 236_ EHQMK 241_ DCPMP 246_ RNAAR 251_ ISEKR 256_ KEYMD 261_ ACGEA 266_ NNQNF 271_ QQRYH 276_ AEEVE 281_ ERFGR 286_ FKPGV 291_ ISEEL 296_ QDALG 301_ VTDKS 306_ LPPFI 311_ YRMRQ 316_ LGYPP 321_ GWLKE 326_ AELEN 331_ SGLAL 336_ YDGKD 341_ GTDGE 346_ TEVGE 351_ IQQNK 356_ SVTYD 361_ LSKLV 366_ NYPGF 371_ NISTP 376_ RGIPD 381_ EWRIF 386_ GSIPM 391_ QACQQ 396_ KDVFA 401_ NYLTS 406_ NFQAP 411_ GVKSG 416_ NKRSS 421_ SHSSP 426_ GSPKK 431_ QKNES 436_ NSAGS 441_ PADME 446_ LDSDM 451_ EVPHG 456_ SQSSE 461_ SFQFQ 466_ PPLPP 471_ DTPPL 476_ PRGTP 481_ PPVFT 486_ PPLPK 491_ GTPPL 496_ TPSDS 501_ PQTRT 506_ ASGAV 511_ DEDAL 516_ TLEEL 521_ EEQQR 526_ RIWAA 531_ LEQAE 536_ SVNSD 541_ SDVPV 546_ DTPLT 551_ GNSVA 556_ SSPCP 561_ NELDL 566_ PVPEG 571_ KTSEK 576_ QTLDE 581_ PEVPE 586_ IFTKK 591_ SEAGH 596_ ASSPD 601_ SEVTS 606_ LCQKE 611_ KAELA 616_ PVNTE 621_ GALLD 626_ NGSVV 631_ PNCDI 636_ SNGGS 641_ QKLFP 646_ ADTSP 651_ STATK 656_ IHSPI 661_ PDMSK 666_ FATGI 671_ TPFEF 676_ ENMAE 681_ STGMY 686_ LRIRS 691_ LLKNS 696_ PRNQQ 701_KNKKA
1: Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing (Probable). It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function (PubMed:31488579)