Cdc42 effector protein 5 (Binder of Rho GTPases 3)
1_MPVLK 6_ QLGPA 11_ QPKKR 16_ PDRGA 21_ LSISA 26_ PLGDF 31_ RHTLH 36_ VGRGG 41_ DAFGD 46_ TSFLS 51_ RHGGG 56_ PPPEP 61_ RAPPA 66_ GAPRS 71_ PPPPA 76_ VPQSA 81_ APSPA 86_ DPLLS 91_ FHLDL 96_ GPSML 101_ DAVLG 106_ VMDAA 111_ RPEAA 116_ AAKPD 121_ AEPRP 126_ GTQPP 131_ QARCR 136_ PNADL 141_ELNDV
1: Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42 (By similarity)