Mitochondrial mRNA pseudouridine synthase RPUSD3 (EC 5.4.99.-) (RNA pseudouridylate synthase domain-containing protein 3)
1_MRAVL 6_ AREMD 11_ GRRVL 16_ GRFWS 21_ GWRRG 26_ LGVRP 31_ VPEDA 36_ GFGTE 41_ ARHQR 46_ QPRGS 51_ CQRSG 56_ PLGDQ 61_ PFAGL 66_ LPKNL 71_ SREEL 76_ VDALR 81_ AAVVD 86_ RKGPL 91_ VTLNK 96_ PQGLP 101_ VTGKP 106_ GELTL 111_ FSVLP 116_ ELSQS 121_ LGLRE 126_ QELQV 131_ VRASG 136_ KESSG 141_ LVLLS 146_ SCPQT 151_ ASRLQ 156_ KYFTH 161_ ARRAQ 166_ RPTAT 171_ YCAVT 176_ DGIPA 181_ ASEGK 186_ IQAAL 191_ KLEHI 196_ DGVNL 201_ TVPVK 206_ APSRK 211_ DILEG 216_ VKKTL 221_ SHFRV 226_ VATGS 231_ GCALV 236_ QLQPL 241_ TVFSS 246_ QLQVH 251_ MVLQL 256_ CPVLG 261_ DHMYS 266_ ARVGT 271_ VLGQR 276_ FLLPA 281_ ENNKP 286_ QRQVL 291_ DEALL 296_ RRLHL 301_ TPSQA 306_ AQLPL 311_ HLHLH 316_ RLLLP 321_ GTRAR 326_ DTPVE 331_ LLAPL 336_ PPYFS 341_ RTLQC 346_LGLRL
1: Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs), a post-transcriptional modification necessary for their translation. Acts at position 390 in COXI mt-mRNA and at position 697-699 in mitochondrial COXIII mt-mRNA (PubMed:27974379). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and may play a role in mitochondrial ribosome biogenesis (PubMed:27667664)