Endoplasmic reticulum aminopeptidase 2 (EC 3.4.11.-) (Leukocyte-derived arginine aminopeptidase) (L-RAP)
1_MFHSS 6_ AMVNS 11_ HRKPM 16_ FNIHR 21_ GFYCL 26_ TAILP 31_ QICIC 36_ SQFSV 41_ PSSYH 46_ FTEDP 51_ GAFPV 56_ ATNGE 61_ RFPWQ 66_ ELRLP 71_ SVVIP 76_ LHYDL 81_ FVHPN 86_ LTSLD 91_ FVASE 96_ KIEVL 101_ VSNAT 106_ QFIIL 111_ HSKDL 116_ EITNA 121_ TLQSE 126_ EDSRY 131_ MKPGK 136_ ELKVL 141_ SYPAH 146_ EQIAL 151_ LVPEK 156_ LTPHL 161_ KYYVA 166_ MDFQA 171_ KLGDG 176_ FEGFY 181_ KSTYR 186_ TLGGE 191_ TRILA 196_ VTDFE 201_ PTQAR 206_ MAFPC 211_ FDEPL 216_ FKANF 221_ SIKIR 226_ RESRH 231_ IALSN 236_ MPKVK 241_ TIELE 246_ GGLLE 251_ DHFET 256_ TVKMS 261_ TYLVA 266_ YIVCD 271_ FHSLS 276_ GFTSS 281_ GVKVS 286_ IYASP 291_ DKRNQ 296_ THYAL 301_ QASLK 306_ LLDFY 311_ EKYFD 316_ IYYPL 321_ SKLDL 326_ IAIPD 331_ FAPGA 336_ MENWG 341_ LITYR 346_ ETSLL 351_ FDPKT 356_ SSASD 361_ KLWVT 366_ RVIAH 371_ ELAHQ 376_ WFGNL 381_ VTMEW 386_ WNDIW 391_ LKEGF 396_ AKYME 401_ LIAVN 406_ ATYPE 411_ LQFDD 416_ YFLNV 421_ CFEVI 426_ TKDSL 431_ NSSRP 436_ ISKPA 441_ ETPTQ 446_ IQEMF 451_ DEVSY 456_ NKGAC 461_ ILNML 466_ KDFLG 471_ EEKFQ 476_ KGIIQ 481_ YLKKF 486_ SYRNA 491_ KNDDL 496_ WSSLS 501_ NSCLE 506_ SDFTS 511_ GGVCH 516_ SDPKM 521_ TSNML 526_ AFLGE 531_ NAEVK 536_ EMMTT 541_ WTLQK 546_ GIPLL 551_ VVKQD 556_ GCSLR 561_ LQQER 566_ FLQGV 571_ FQEDP 576_ EWRAL 581_ QERYL 586_ WHIPL 591_ TYSTS 596_ SSNVI 601_ HRHIL 606_ KSKTD 611_ TLDLP 616_ EKTSW 621_ VKFNV 626_ DSNGY 631_ YIVHY 636_ EGHGW 641_ DQLIT 646_ QLNQN 651_ HTLLR 656_ PKDRV 661_ GLIHD 666_ VFQLV 671_ GAGRL 676_ TLDKA 681_ LDMTY 686_ YLQHE 691_ TSSPA 696_ LLEGL 701_ SYLES 706_ FYHMM 711_ DRRNI 716_ SDISE 721_ NLKRY 726_ LLQYF 731_ KPVID 736_ RQSWS 741_ DKGSV 746_ WDRML 751_ RSALL 756_ KLACD 761_ LNHAP 766_ CIQKA 771_ AELFS 776_ QWMES 781_ SGKLN 786_ IPTDV 791_ LKIVY 796_ SVGAQ 801_ TTAGW 806_ NYLLE 811_ QYELS 816_ MSSAE 821_ QNKIL 826_ YALST 831_ SKHQE 836_ KLLKL 841_ IELGM 846_ EGKVI 851_ KTQNL 856_ AALLH 861_ AIARR 866_ PKGQQ 871_ LAWDF 876_ VRENW 881_ THLLK 886_ KFDLG 891_ SYDIR 896_ MIISG 901_ TTAHF 906_ SSKDK 911_ LQEVK 916_ LFFES 921_ LEAQG 926_ SHLDI 931_ FQTVL 936_ ETITK 941_ NIKWL 946_ EKNLP 951_TLRTW
1: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys