Lysophospholipid acyltransferase 5 (LPLAT 5) (EC 2.3.1.-) (1-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.23) (1-acylglycerophosphoethanolamine O-acyltransferase) (EC 2.3.1.n7) (1-acylglycerophosphoserine O-acyltransferase) (EC 2.3.1.n6) (Lysophosphatidylcholine acyltransferase) (LPCAT) (Lyso-PC acyltransferase) (Lysophosphatidylcholine acyltransferase 3) (Lyso-PC acyltransferase 3) (Lysophosphatidylserine acyltransferase) (LPSAT) (Lyso-PS acyltransferase) (Membrane-bound O-acyltransferase domain-containing protein 5) (O-acyltransferase domain-containing protein 5)
1_MASSA 6_ EGDEG 11_ TVVAL 16_ AGVLQ 21_ SGFQE 26_ LSLNK 31_ LATSL 36_ GASEQ 41_ ALRLI 46_ ISIFL 51_ GYPFA 56_ LFYRH 61_ YLFYK 66_ ETYLI 71_ HLFHT 76_ FTGLS 81_ IAYFN 86_ FGNQL 91_ YHSLL 96_ CIVLQ 101_ FLILR 106_ LMGRT 111_ ITAVL 116_ TTFCF 121_ QMAYL 126_ LAGYY 131_ YTATG 136_ NYDIK 141_ WTMPH 146_ CVLTL 151_ KLIGL 156_ AVDYF 161_ DGGKD 166_ QNSLS 171_ SEQQK 176_ YAIRG 181_ VPSLL 186_ EVAGF 191_ SYFYG 196_ AFLVG 201_ PQFSM 206_ NHYMK 211_ LVQGE 216_ LIDIP 221_ GKIPN 226_ SIIPA 231_ LKRLS 236_ LGLFY 241_ LVGYT 246_ LLSPH 251_ ITEDY 256_ LLTED 261_ YDNHP 266_ FWFRC 271_ MYMLI 276_ WGKFV 281_ LYKYV 286_ TCWLV 291_ TEGVC 296_ ILTGL 301_ GFNGF 306_ EEKGK 311_ AKWDA 316_ CANMK 321_ VWLFE 326_ TNPRF 331_ TGTIA 336_ SFNIN 341_ TNAWV 346_ ARYIF 351_ KRLKF 356_ LGNKE 361_ LSQGL 366_ SLLFL 371_ ALWHG 376_ LHSGY 381_ LVCFQ 386_ MEFLI 391_ VIVER 396_ QAARL 401_ IQESP 406_ TLSKL 411_ AAITV 416_ LQPFY 421_ YLVQQ 426_ TIHWL 431_ FMGYS 436_ MTAFC 441_ LFTWD 446_ KWLKV 451_ YKSIY 456_ FLGHI 461_ FFLSL 466_ LFILP 471_ YIHKA 476_ MVPRK 481_EKLKK
1: Lysophospholipid O-acyltransferase (LPLAT) that catalyzes the reacylation step of the phospholipid remodeling process also known as the Lands cycle (PubMed:18195019, PubMed:18772128, PubMed:18782225). Catalyzes transfer of the fatty acyl chain from fatty acyl-CoA to 1-acyl lysophospholipid to form various classes of phospholipids. Converts 1-acyl lysophosphatidylcholine (LPC) into phosphatidylcholine (PC) (LPCAT activity), 1-acyl lysophosphatidylserine (LPS) into phosphatidylserine (PS) (LPSAT activity) and 1-acyl lysophosphatidylethanolamine (LPE) into phosphatidylethanolamine (PE) (LPEAT activity) (PubMed:18195019, PubMed:18772128, PubMed:18782225). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs (PubMed:18195019, PubMed:18772128). Has higher activity for LPC acyl acceptors compared to LPEs and LPSs. Can also transfer the fatty acyl chain from fatty acyl-CoA to 1-O-alkyl lysophospholipid or 1-O-alkenyl lysophospholipid with lower efficiency (By similarity). Acts as a major LPC O-acyltransferase in liver and intestine. As a component of the liver X receptor/NR1H3 or NR1H2 signaling pathway, mainly catalyzes the incorporation of arachidonate into PCs of endoplasmic reticulum (ER) membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Promotes processing of sterol regulatory protein SREBF1 in hepatocytes, likely by facilitating the translocation of SREBF1-SCAP complex from ER to the Golgi apparatus (By similarity). Participates in mechanisms by which the liver X receptor/NR1H3 or NR1H2 signaling pathway counteracts lipid-induced ER stress response and inflammation. Down-regulates hepatic inflammation by limiting arachidonic acid availability for synthesis of inflammatory eicosanoids, such as prostaglandins (By similarity). In enterocytes, acts as a component of a gut-brain feedback loop that coordinates dietary lipid absorption and food intake. Regulates the abundance of PCs containing linoleate and arachidonate in enterocyte membranes, enabling passive diffusion of fatty acids and cholesterol across the membrane for efficient chylomicron assembly (By similarity). In the intestinal crypt, acts as a component of dietary-responsive phospholipid-cholesterol axis, regulating the biosynthesis of cholesterol and its mitogenic effects on intestinal stem cells (By similarity)