Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein)
1_MADVL 6_ SVLRQ 11_ YNIQK 16_ KEIVV 21_ KGDEV 26_ IFGEF 31_ SWPKN 36_ VKTNY 41_ VVWGT 46_ GKEGQ 51_ PREYY 56_ TLDSI 61_ LFLLN 66_ NVHLS 71_ HPVYV 76_ RRAAT 81_ ENIPV 86_ VRRPD 91_ RKDLL 96_ GYLNG 101_ EASTS 106_ ASIDR 111_ SAPLE 116_ IGLQR 121_ STQVK 126_ RAADE 131_ VLAEA 136_ KKPRI 141_ EDEEC 146_ VRLDK 151_ ERLAA 156_ RLEGH 161_ KEGIV 166_ QTEQI 171_ RSLSE 176_ AMSVE 181_ KIAAI 186_ KAKIM 191_ AKKRS 196_ TIKTD 201_ LDDDI 206_ TALKQ 211_ RSFVD 216_ AEVDV 221_ TRDIV 226_ SRERV 231_ WRTRT 236_ TILQS 241_ TGKNF 246_ SKNIF 251_ AILQS 256_ VKARE 261_ EGRAP 266_ EQRPA 271_ PNAAP 276_ VDPTL 281_ RTKQP 286_ IPAAY 291_ NRYDQ 296_ ERFKG 301_ KEETE 306_ GFKID 311_ TMGTY 316_ HGMTL 321_ KSVTE 326_ GASAR 331_ KTQTP 336_ AAQPV 341_ PRPVS 346_ QARPP 351_ PNQKK 356_ GSRTP 361_ IIIIP 366_ AATTS 371_ LITML 376_ NAKDL 381_ LQDLK 386_ FVPSD 391_ EKKKQ 396_ GCQRE 401_ NETLI 406_ QRRKD 411_ QMQPG 416_ GTAIS 421_ VTVPY 426_ RVVDQ 431_ PLKLM 436_ PQDWD 441_ RVVAV 446_ FVQGP 451_ AWQFK 456_ GWPWL 461_ LPDGS 466_ PVDIF 471_ AKIKA 476_ FHLKY 481_ DEVRL 486_ DPNVQ 491_ KWDVT 496_ VLELS 501_ YHKRH 506_ LDRPV 511_ FLRFW 516_ ETLDR 521_ YMVKH 526_KSHLR
1: Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling. Involved in polyadenylation of mRNA precursors