Coiled-coil and C2 domain-containing protein 1A (Akt kinase-interacting protein 1) (Five prime repressor element under dual repression-binding protein 1) (FRE under dual repression-binding protein 1) (Freud-1) (Putative NF-kappa-B-activating protein 023N)
1_MHKRK 6_ GPPGP 11_ PGRGA 16_ AAARQ 21_ LGLLV 26_ DLSPD 31_ GLMIP 36_ EDGAN 41_ DEELE 46_ AEFLA 51_ LVGGQ 56_ PPALE 61_ KLKGK 66_ GPLPM 71_ EAIEK 76_ MASLC 81_ MRDPD 86_ EDEEE 91_ GTDED 96_ DLEAD 101_ DDLLA 106_ ELNEV 111_ LGEEQ 116_ KASET 121_ PPPVA 126_ QPKPE 131_ APHPG 136_ LETTL 141_ QERLA 146_ LYQTA 151_ IESAR 156_ QAGDS 161_ AKMRR 166_ YDRGL 171_ KTLEN 176_ LLASI 181_ RKGNA 186_ IDEAD 191_ IPPPV 196_ AIGKG 201_ PASTP 206_ TYSPA 211_ PTQPA 216_ PRIAS 221_ APEPR 226_ VTLEG 231_ PSATA 236_ PASSP 241_ GLAKP 246_ QMPPG 251_ PCSPG 256_ PLAQL 261_ QSRQR 266_ DYKLA 271_ ALHAK 276_ QQGDT 281_ TAAAR 286_ HFRVA 291_ KSFDA 296_ VLEAL 301_ SRGEP 306_ VDLSC 311_ LPPPP 316_ DQLPP 321_ DPPSP 326_ PSQPP 331_ TPATA 336_ PSTTE 341_ VPPPP 346_ RTLLE 351_ ALEQR 356_ MERYQ 361_ VAAAQ 366_ AKSKG 371_ DQRKA 376_ RMHER 381_ IVKQY 386_ QDAIR 391_ AHKAG 396_ RAVDV 401_ AELPV 406_ PPGFP 411_ PIQGL 416_ EATKP 421_ TQQSL 426_ VGVLE 431_ TAMKL 436_ ANQDE 441_ GPEDE 446_ EDEVP 451_ KKQNS 456_ PVAPT 461_ AQPKA 466_ PPSRT 471_ PQSGS 476_ APTAK 481_ APPKA 486_ TSTRA 491_ QQQLA 496_ FLEGR 501_ KKQLL 506_ QAALR 511_ AKQKN 516_ DVEGA 521_ KMHLR 526_ QAKGL 531_ EPMLE 536_ ASRNG 541_ LPVDI 546_ TKVPP 551_ APVNK 556_ DDFAL 561_ VQRPG 566_ PGLSQ 571_ EAARR 576_ YGELT 581_ KLIRQ 586_ QHEMC 591_ LNHSN 596_ QFTQL 601_ GNITE 606_ TTKFE 611_ KLAED 616_ CKRSM 621_ DILKQ 626_ AFVRG 631_ LPTPT 636_ ARFEQ 641_ RTFSV 646_ IKIFP 651_ DLSSN 656_ DMLLF 661_ IVKGI 666_ NLPTP 671_ PGLSP 676_ GDLDV 681_ FVRFD 686_ FPYPN 691_ VEEAQ 696_ KDKTS 701_ VIKNT 706_ DSPEF 711_ KEQFK 716_ LCINR 721_ SHRGF 726_ RRAIQ 731_ TKGIK 736_ FEVVH 741_ KGGLF 746_ KTDRV 751_ LGTAQ 756_ LKLDA 761_ LEIAC 766_ EVREI 771_ LEVLD 776_ GRRPT 781_ GGRLE 786_ VMVRI 791_ REPLT 796_ AQQLE 801_ TTTER 806_ WLVID 811_ PVPAA 816_ VPTQV 821_ AGPKG 826_ KAPPV 831_ PAPAR 836_ ESGNR 841_ SARPL 846_ HSLSV 851_ LAFDQ 856_ ERLER 861_ KILAL 866_ RQARR 871_ PVPPE 876_ VAQQY 881_ QDIMQ 886_ RSQWQ 891_ RAQLE 896_ QGGVG 901_ IRREY 906_ AAQLE 911_ RQLQF 916_ YTEAA 921_ RRLGN 926_ DGSRD 931_ AAKEA 936_ LYRRN 941_ LVESE 946_LQRLR
1: Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis