LETM1 domain-containing protein 1 (Cervical cancer 1 proto-oncogene protein p40) (Cervical cancer proto-oncogene 2 protein) (HCCR-1) (HCRR-2)
1_MALSR 6_ VCWAR 11_ SAVWG 16_ SAVTP 21_ GHFVT 26_ RRLQL 31_ GRSGL 36_ AWGAP 41_ RSSKL 46_ HLSPK 51_ ADVKN 56_ LMSYV 61_ VTKTK 66_ AINGK 71_ YHRFL 76_ GRHFP 81_ RFYVL 86_ YTIFM 91_ KGLQM 96_ LWADA 101_ KKARR 106_ IKTNM 111_ WKHNI 116_ KFHQL 121_ PYREM 126_ EHLRQ 131_ FRQDV 136_ TKCLF 141_ LGIIS 146_ IPPFA 151_ NYLVF 156_ LLMYL 161_ FPRQL 166_ LIRHF 171_ WTPKQ 176_ QTDFL 181_ DIYHA 186_ FRKQS 191_ HPEII 196_ SYLEK 201_ VIPLI 206_ SDAGL 211_ RWRLT 216_ DLCTK 221_ IQRGT 226_ HPAIH 231_ DILAL 236_ RECFS 241_ NHPLG 246_ MNQLQ 251_ ALHVK 256_ ALSRA 261_ MLLTS 266_ YLPPP 271_ LLRHR 276_ LKTHT 281_ TVIHQ 286_ LDKAL 291_ AKLGI 296_ GQLTA 301_ QEVKS 306_ ACYLR 311_ GLNST 316_ HIGED 321_ RCRTW 326_ LGEWL 331_ QISCS 336_ LKEAE 341_ LSLLL 346_ HNVVL 351_LSTNY
1: Plays an essential role for mitochondrial structure and function, as well as thermogenesis of brown adipocytes. In brown adipose tissue also localizes in the nucleus where it interacts with the chromatin remodeler SMARCA4 to regulate thermogenic genes expression, such as UCP1 (By similarity). May regulate phagocytosis and inflammatory responses to lipopolysaccharide in macrophages (PubMed:31980577). Involved in tumorigenesis and may function as a negative regulator of the p53/TP53 (PubMed:12879013)