Mediator of RNA polymerase II transcription subunit 27 (Cofactor required for Sp1 transcriptional activation subunit 8) (CRSP complex subunit 8) (Mediator complex subunit 27) (P37 TRAP/SMCC/PC2 subunit) (Transcriptional coactivator CRSP34)
1_MADVI 6_ NVSVN 11_ LEAFS 16_ QAISA 21_ IQALR 26_ SSVSR 31_ VFDCL 36_ KDGMR 41_ NKETL 46_ EGREK 51_ AFIAH 56_ FQDNL 61_ HSVNR 66_ DLNEL 71_ ERLSN 76_ LVGKP 81_ SENHP 86_ LHNSG 91_ LLSLD 96_ PVQDK 101_ TPLYS 106_ QLLQA 111_ YKWSN 116_ KLQYH 121_ AGLAS 126_ GLLNQ 131_ QSLKR 136_ SANQM 141_ GVSAK 146_ RRPKA 151_ QPTTL 156_ VLPPQ 161_ YVDDV 166_ ISRID 171_ RMFPE 176_ MSIHL 181_ SRPNG 186_ TSAML 191_ LVTLG 196_ KVLKV 201_ IVVMR 206_ SLFID 211_ RTIVK 216_ GYNEN 221_ VYTED 226_ GKLDI 231_ WSKSN 236_ YQVFQ 241_ KVTDH 246_ ATTAL 251_ LHYQL 256_ PQMPD 261_ VVVRS 266_ FMTWL 271_ RSYIK 276_ LFQAP 281_ CQRCG 286_ KFLQD 291_ GLPPT 296_ WRDFR 301_ TLEAF 306_HDTCR
1: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors