Centrosomal protein of 85 kDa (Cep85) (Coiled-coil domain-containing protein 21)
1_MAMQE 6_ KYPTE 11_ GISHV 16_ TSPSS 21_ DVIQK 26_ GSSLG 31_ TEWQT 36_ PVISE 41_ PFRSR 46_ FSRCS 51_ SVADS 56_ GDTAI 61_ GTSCS 66_ DIAED 71_ FCSSS 76_ GSPPF 81_ QPIKS 86_ HVTIP 91_ TAHVM 96_ PSTLG 101_ TSPAK 106_ PNSTP 111_ VGPSS 116_ SKLPL 121_ SGLAE 126_ SVGMT 131_ RNGDL 136_ GAMKH 141_ SPGLS 146_ RDLMY 151_ FSGAT 156_ GENGI 161_ EQSWF 166_ PAVGH 171_ ERQEE 176_ ARKFD 181_ IPSME 186_ STLNQ 191_ SAMME 196_ TLYSD 201_ PHHRV 206_ RFHNP 211_ RTSTS 216_ KELYR 221_ VLPEA 226_ KKAPG 231_ SGAVF 236_ ERNGP 241_ HSNSS 246_ GVLPL 251_ GLQPA 256_ PGLSK 261_ PLPSQ 266_ VWQPS 271_ PDTWH 276_ PREQS 281_ CELST 286_ CRQQL 291_ ELIRL 296_ QMEQM 301_ QLQNG 306_ AICHH 311_ PAAFG 316_ PSLPI 321_ LEPAQ 326_ WISIL 331_ NSNEH 336_ LLKEK 341_ ELLID 346_ KQRKH 351_ ISQLE 356_ QKVRE 361_ SELQV 366_ HSALL 371_ GRPAP 376_ FGDVC 381_ LLRLQ 386_ ELQRE 391_ NTFLR 396_ AQFAQ 401_ KTEAL 406_ SREKI 411_ DLEKK 416_ LSASE 421_ VEVQL 426_ IRESL 431_ KVALQ 436_ KHSEE 441_ VKKQE 446_ ERVKG 451_ RDKHI 456_ NNLKK 461_ KCQKE 466_ SEQNR 471_ EKQQR 476_ IETLE 481_ RYLAD 486_ LPTLE 491_ DHQKQ 496_ SQQLK 501_ DSELK 506_ STELQ 511_ EKVTE 516_ LESLL 521_ EETQA 526_ ICREK 531_ EIQLE 536_ SLRQR 541_ EAEFS 546_ SAGHS 551_ LQDKQ 556_ SVEET 561_ SGEGP 566_ EVEME 571_ SWQKR 576_ YDSLQ 581_ KIVEK 586_ QQQKM 591_ DQLRS 596_ QVQSL 601_ EQEVA 606_ QEEGT 611_ SQALR 616_ EEAQR 621_ RDSAL 626_ QQLRT 631_ AVKEL 636_ SVQNQ 641_ DLIEK 646_ NLTLQ 651_ EHLRQ 656_ AQPGS 661_ PPSPD 666_ TAQLA 671_ LELHQ 676_ ELASC 681_ LQDLQ 686_ AVCSI 691_ VTQRA 696_ QGHDP 701_ NLSLL 706_ LGIHS 711_ AQHPE 716_ TQLDL 721_ QKPDV 726_ IKRKL 731_ EEVQQ 736_ LRRDI 741_ EDLRT 746_ TMSDR 751_ YAQDM 756_GENCV
1: Acts as a regulator of centriole duplication through a direct interaction with STIL, a key factor involved in the early steps of centriole formation. The CEP85-STIL protein complex acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility (PubMed:29712910, PubMed:32107292). Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity (PubMed:26220856)