Pre-mRNA-processing-splicing factor 8 (220 kDa U5 snRNP-specific protein) (PRP8 homolog) (Splicing factor Prp8) (p220)
1_MAGVF 6_ PYRGP 11_ GNPVP 16_ GPLAP 21_ LPDYM 26_ SEEKL 31_ QEKAR 36_ KWQQL 41_ QAKRY 46_ AEKRK 51_ FGFVD 56_ AQKED 61_ MPPEH 66_ VRKII 71_ RDHGD 76_ MTNRK 81_ FRHDK 86_ RVYLG 91_ ALKYM 96_ PHAVL 101_ KLLEN 106_ MPMPW 111_ EQIRD 116_ VPVLY 121_ HITGA 126_ ISFVN 131_ EIPWV 136_ IEPVY 141_ ISQWG 146_ SMWIM 151_ MRREK 156_ RDRRH 161_ FKRMR 166_ FPPFD 171_ DEEPP 176_ LDYAD 181_ NILDV 186_ EPLEA 191_ IQLEL 196_ DPEED 201_ APVLD 206_ WFYDH 211_ QPLRD 216_ SRKYV 221_ NGSTY 226_ QRWQF 231_ TLPMM 236_ STLYR 241_ LANQL 246_ LTDLV 251_ DDNYF 256_ YLFDL 261_ KAFFT 266_ SKALN 271_ MAIPG 276_ GPKFE 281_ PLVRD 286_ INLQD 291_ EDWNE 296_ FNDIN 301_ KIIIR 306_ QPIRT 311_ EYKIA 316_ FPYLY 321_ NNLPH 326_ HVHLT 331_ WYHTP 336_ NVVFI 341_ KTEDP 346_ DLPAF 351_ YFDPL 356_ INPIS 361_ HRHSV 366_ KSQEP 371_ LPDDD 376_ EEFEL 381_ PEFVE 386_ PFLKD 391_ TPLYT 396_ DNTAN 401_ GIALL 406_ WAPRP 411_ FNLRS 416_ GRTRR 421_ ALDIP 426_ LVKNW 431_ YREHC 436_ PAGQP 441_ VKVRV 446_ SYQKL 451_ LKYYV 456_ LNALK 461_ HRPPK 466_ AQKKR 471_ YLFRS 476_ FKATK 481_ FFQST 486_ KLDWV 491_ EVGLQ 496_ VCRQG 501_ YNMLN 506_ LLIHR 511_ KNLNY 516_ LHLDY 521_ NFNLK 526_ PVKTL 531_ TTKER 536_ KKSRF 541_ GNAFH 546_ LCREV 551_ LRLTK 556_ LVVDS 561_ HVQYR 566_ LGNVD 571_ AFQLA 576_ DGLQY 581_ IFAHV 586_ GQLTG 591_ MYRYK 596_ YKLMR 601_ QIRMC 606_ KDLKH 611_ LIYYR 616_ FNTGP 621_ VGKGP 626_ GCGFW 631_ AAGWR 636_ VWLFF 641_ MRGIT 646_ PLLER 651_ WLGNL 656_ LARQF 661_ EGRHS 666_ KGVAK 671_ TVTKQ 676_ RVESH 681_ FDLEL 686_ RAAVM 691_ HDILD 696_ MMPEG 701_ IKQNK 706_ ARTIL 711_ QHLSE 716_ AWRCW 721_ KANIP 726_ WKVPG 731_ LPTPI 736_ ENMIL 741_ RYVKA 746_ KADWW 751_ TNTAH 756_ YNRER 761_ IRRGA 766_ TVDKT 771_ VCKKN 776_ LGRLT 781_ RLYLK 786_ AEQER 791_ QHNYL 796_ KDGPY 801_ ITAEE 806_ AVAVY 811_ TTTVH 816_ WLESR 821_ RFSPI 826_ PFPPL 831_ SYKHD 836_ TKLLI 841_ LALER 846_ LKEAY 851_ SVKSR 856_ LNQSQ 861_ REELG 866_ LIEQA 871_ YDNPH 876_ EALSR 881_ IKRHL 886_ LTQRA 891_ FKEVG 896_ IEFMD 901_ LYSHL 906_ VPVYD 911_ VEPLE 916_ KITDA 921_ YLDQY 926_ LWYEA 931_ DKRRL 936_ FPPWI 941_ KPADT 946_ EPPPL 951_ LVYKW 956_ CQGIN 961_ NLQDV 966_ WETSE 971_ GECNV 976_ MLESR 981_ FEKMY 986_ EKIDL 991_ TLLNR 996_ LLRLI 1001_ VDHNI 1006_ ADYMT 1011_ AKNNV 1016_ VINYK 1021_ DMNHT 1026_ NSYGI 1031_ IRGLQ 1036_ FASFI 1041_ VQYYG 1046_ LVMDL 1051_ LVLGL 1056_ HRASE 1061_ MAGPP 1066_ QMPND 1071_ FLSFQ 1076_ DIATE 1081_ AAHPI 1086_ RLFCR 1091_ YIDRI 1096_ HIFFR 1101_ FTADE 1106_ ARDLI 1111_ QRYLT 1116_ EHPDP 1121_ NNENI 1126_ VGYNN 1131_ KKCWP 1136_ RDARM 1141_ RLMKH 1146_ DVNLG 1151_ RAVFW 1156_ DIKNR 1161_ LPRSV 1166_ TTVQW 1171_ ENSFV 1176_ SVYSK 1181_ DNPNL 1186_ LFNMC 1191_ GFECR 1196_ ILPKC 1201_ RTSYE 1206_ EFTHK 1211_ DGVWN 1216_ LQNEV 1221_ TKERT 1226_ AQCFL 1231_ RVDDE 1236_ SMQRF 1241_ HNRVR 1246_ QILMA 1251_ SGSTT 1256_ FTKIV 1261_ NKWNT 1266_ ALIGL 1271_ MTYFR 1276_ EAVVN 1281_ TQELL 1286_ DLLVK 1291_ CENKI 1296_ QTRIK 1301_ IGLNS 1306_ KMPSR 1311_ FPPVV 1316_ FYTPK 1321_ ELGGL 1326_ GMLSM 1331_ GHVLI 1336_ PQSDL 1341_ RWSKQ 1346_ TDVGI 1351_ THFRS 1356_ GMSHE 1361_ EDQLI 1366_ PNLYR 1371_ YIQPW 1376_ ESEFI 1381_ DSQRV 1386_ WAEYA 1391_ LKRQE 1396_ AIAQN 1401_ RRLTL 1406_ EDLED 1411_ SWDRG 1416_ IPRIN 1421_ TLFQK 1426_ DRHTL 1431_ AYDKG 1436_ WRVRT 1441_ DFKQY 1446_ QVLKQ 1451_ NPFWW 1456_ THQRH 1461_ DGKLW 1466_ NLNNY 1471_ RTDMI 1476_ QALGG 1481_ VEGIL 1486_ EHTLF 1491_ KGTYF 1496_ PTWEG 1501_ LFWEK 1506_ ASGFE 1511_ ESMKW 1516_ KKLTN 1521_ AQRSG 1526_ LNQIP 1531_ NRRFT 1536_ LWWSP 1541_ TINRA 1546_ NVYVG 1551_ FQVQL 1556_ DLTGI 1561_ FMHGK 1566_ IPTLK 1571_ ISLIQ 1576_ IFRAH 1581_ LWQKI 1586_ HESIV 1591_ MDLCQ 1596_ VFDQE 1601_ LDALE 1606_ IETVQ 1611_ KETIH 1616_ PRKSY 1621_ KMNSS 1626_ CADIL 1631_ LFASY 1636_ KWNVS 1641_ RPSLL 1646_ ADSKD 1651_ VMDST 1656_ TTQKY 1661_ WIDIQ 1666_ LRWGD 1671_ YDSHD 1676_ IERYA 1681_ RAKFL 1686_ DYTTD 1691_ NMSIY 1696_ PSPTG 1701_ VLIAI 1706_ DLAYN 1711_ LHSAY 1716_ GNWFP 1721_ GSKPL 1726_ IQQAM 1731_ AKIMK 1736_ ANPAL 1741_ YVLRE 1746_ RIRKG 1751_ LQLYS 1756_ SEPTE 1761_ PYLSS 1766_ QNYGE 1771_ LFSNQ 1776_ IIWFV 1781_ DDTNV 1786_ YRVTI 1791_ HKTFE 1796_ GNLTT 1801_ KPING 1806_ AIFIF 1811_ NPRTG 1816_ QLFLK 1821_ IIHTS 1826_ VWAGQ 1831_ KRLGQ 1836_ LAKWK 1841_ TAEEV 1846_ AALIR 1851_ SLPVE 1856_ EQPKQ 1861_ IIVTR 1866_ KGMLD 1871_ PLEVH 1876_ LLDFP 1881_ NIVIK 1886_ GSELQ 1891_ LPFQA 1896_ CLKVE 1901_ KFGDL 1906_ ILKAT 1911_ EPQMV 1916_ LFNLY 1921_ DDWLK 1926_ TISSY 1931_ TAFSR 1936_ LILIL 1941_ RALHV 1946_ NNDRA 1951_ KVILK 1956_ PDKTT 1961_ ITEPH 1966_ HIWPT 1971_ LTDEE 1976_ WIKVE 1981_ VQLKD 1986_ LILAD 1991_ YGKKN 1996_ NVNVA 2001_ SLTQS 2006_ EIRDI 2011_ ILGME 2016_ ISAPS 2021_ QQRQQ 2026_ IAEIE 2031_ KQTKE 2036_ QSQLT 2041_ ATQTR 2046_ TVNKH 2051_ GDEII 2056_ TSTTS 2061_ NYETQ 2066_ TFSSK 2071_ TEWRV 2076_ RAISA 2081_ ANLHL 2086_ RTNHI 2091_ YVSSD 2096_ DIKET 2101_ GYTYI 2106_ LPKNV 2111_ LKKFI 2116_ CISDL 2121_ RAQIA 2126_ GYLYG 2131_ VSPPD 2136_ NPQVK 2141_ EIRCI 2146_ VMVPQ 2151_ WGTHQ 2156_ TVHLP 2161_ GQLPQ 2166_ HEYLK 2171_ EMEPL 2176_ GWIHT 2181_ QPNES 2186_ PQLSP 2191_ QDVTT 2196_ HAKIM 2201_ ADNPS 2206_ WDGEK 2211_ TIIIT 2216_ CSFTP 2221_ GSCTL 2226_ TAYKL 2231_ TPSGY 2236_ EWGRQ 2241_ NTDKG 2246_ NNPKG 2251_ YLPSH 2256_ YERVQ 2261_ MLLSD 2266_ RFLGF 2271_ FMVPA 2276_ QSSWN 2281_ YNFMG 2286_ VRHDP 2291_ NMKYE 2296_ LQLAN 2301_ PKEFY 2306_ HEVHR 2311_ PSHFL 2316_ NFALL 2321_ QEGEV 2326_YSADR
1: Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome (PubMed:10411133, PubMed:11971955, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30315277, PubMed:30705154, PubMed:30728453). Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as a scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site