DENN domain-containing protein 1B (Connecdenn 2) (Protein FAM31B)
1_MDCRT 6_ KANPD 11_ RTFDL 16_ VLKVK 21_ CHASE 26_ NEDPV 31_ VLWKF 36_ PEDFG 41_ DQEIL 46_ QSVPK 51_ FCFPF 56_ DVERV 61_ SQNQV 66_ GQHFT 71_ FVLTD 76_ IESKQ 81_ RFGFC 86_ RLTSG 91_ GTICL 96_ CILSY 101_ LPWFE 106_ VYYKL 111_ LNTLA 116_ DYLAK 121_ ELEND 126_ LNETL 131_ RSLYN 136_ HPVPK 141_ ANTPV 146_ NLSVN 151_ QEIFI 156_ ACEQV 161_ LKDQP 166_ ALVPH 171_ SYFIA 176_ PDVTG 181_ LPTIP 186_ ESRNL 191_ TEYFV 196_ AVDVN 201_ NMLQL 206_ YASML 211_ HERRI 216_ VIISS 221_ KLSTL 226_ TACIH 231_ GSAAL 236_ LYPMY 241_ WQHIY 246_ IPVLP 251_ PHLLD 256_ YCCAP 261_ MPYLI 266_ GIHSS 271_ LIERV 276_ KNKSL 281_ EDVVM 286_ LNVDT 291_ NTLES 296_ PFSDL 301_ NNLPS 306_ DVVSA 311_ LKNKL 316_ KKQST 321_ ATGDG 326_ VARAF 331_ LRAQA 336_ ALFGS 341_ YRDAL 346_ RYKPG 351_ EPITF 356_ CEESF 361_ VKHRS 366_ SVMKQ 371_ FLETA 376_ INLQL 381_ FKQFI 386_ DGRLA 391_ KLNAG 396_ RGFSD 401_ VFEEE 406_ ITSGG 411_ FCGGN 416_ PRSYQ 421_ QWVHT 426_ VKKGG 431_ ALFNT 436_ AMTKA 441_ TPAVR 446_ TAYKF 451_ AKNHA 456_ KLGLK 461_ EVKSK 466_ LKHKE 471_ NEEDY 476_ GTCSS 481_ SVQYT 486_ PVYKL 491_ HNEKG 496_ GNSEK 501_ RKLAQ 506_ ARLKR 511_ PLKSL 516_ DGALY 521_ DDEDD 526_ DDIER 531_ ASKLS 536_ SEDGE 541_ EASAY 546_ LYESD 551_ DSVET 556_ RVKTP 561_ YSGEM 566_ DLLGE 571_ ILDTL 576_ STHSS 581_ DQGKL 586_ AAAKS 591_ LDFFR 596_ SMDDI 601_ DYKPT 606_ NKSNA 611_ PSENN 616_ LAFLC 621_ GGSGD 626_ QAEWN 631_ LGQDD 636_ SALHG 641_ KHLPP 646_ SPRKR 651_ VSSSG 656_ LTDSL 661_ FILKE 666_ ENSNK 671_ HLGAD 676_ NVSDP 681_ TSGLD 686_ FQLTS 691_ PEVSQ 696_ TDKGK 701_ TEKRE 706_ TLSQI 711_ SDDLL 716_ IPGLG 721_ RHSST 726_ FVPWE 731_ KEGKE 736_ AKETS 741_ EDIGL 746_ LHEVV 751_ SLCHM 756_ TSDFQ 761_ QSLNI 766_SDKNT
1: Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells (PubMed:20154091, PubMed:20937701, PubMed:24520163, PubMed:26774822). Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form (PubMed:20154091, PubMed:20937701). Plays a role in clathrin-mediated endocytosis (PubMed:20154091). Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity (PubMed:26774822). Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells (PubMed:26774822)