Alpha-(1,3)-fucosyltransferase 10 (EC 2.4.1.-) (Fucosyltransferase X) (Fuc-TX) (FucT-X) (Galactoside 3-L-fucosyltransferase 10) (Fucosyltransferase 10)
1_MVRIQ 6_ RRKLL 11_ ASCLC 16_ VTATV 21_ FLLVT 26_ LQVMV 31_ ELGKF 36_ ERKEF 41_ KSSSL 46_ QDGHT 51_ KMEEA 56_ PTHLN 61_ SFLKK 66_ EGLTF 71_ NRKRK 76_ WELDS 81_ YPIML 86_ WWSPL 91_ TGETG 96_ RLGQC 101_ GADAC 106_ FFTIN 111_ RTYLH 116_ HHMTK 121_ AFLFY 126_ GTDFN 131_ IDSLP 136_ LPRKA 141_ HHDWA 146_ VFHEE 151_ SPKNN 156_ YKLFH 161_ KPVIT 166_ LFNYT 171_ ATFSR 176_ HSHLP 181_ LTTQY 186_ LESIE 191_ VLKSL 196_ RYLVP 201_ LQSKN 206_ KLRKR 211_ LAPLV 216_ YVQSD 221_ CDPPS 226_ DRDSY 231_ VRELM 236_ TYIEV 241_ DSYGE 246_ CLRNK 251_ DLPQQ 256_ LKNPA 261_ SMDAD 266_ GFYRI 271_ IAQYK 276_ FILAF 281_ ENAVC 286_ DDYIT 291_ EKFWR 296_ PLKLG 301_ VVPVY 306_ YGSPS 311_ ITDWL 316_ PSNKS 321_ AILVS 326_ EFSHP 331_ RELAS 336_ YIRRL 341_ DSDDR 346_ LYEAY 351_ VEWKL 356_ KGEIS 361_ NQRLL 366_ TALRE 371_ RKWGV 376_ QDVNQ 381_ DNYID 386_ AFECM 391_ VCTKV 396_ WANIR 401_ LQEKG 406_ LPPKR 411_ WEAED 416_ THLSC 421_ PEPTV 426_ FAFSP 431_ LRTPP 436_ LSSLR 441_ EMWIS 446_ SFEQS 451_ KKEAQ 456_ ALRWL 461_ VDRNQ 466_ NFSSQ 471_EFWGL
1: Protein O-fucosyltransferase that specifically catalyzes O-fucosylation of serine or threonine residues in EMI domains of target proteins, such as MMRN1, MMRN2 and EMID1 (PubMed:39775168). Attaches fucose through an O-glycosidic linkage (PubMed:39775168). O-fucosylation of EMI domain-containing proteins may be required for facilitating protein folding and secretion (PubMed:39775168). May also show alpha-(1,3)-fucosyltransferase activity toward the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors (PubMed:19088067). However, this was tested with a library of synthetic substrates and this activity is unsure in vivo (PubMed:19088067). May be involved in biosynthesis of Lewis X-carrying biantennary N-glycans that regulate neuron stem cell self-renewal during brain development (By similarity)