Ferredoxin-2, mitochondrial (Adrenodoxin-like protein) (Ferredoxin-1-like protein)
1_MHVMA 6_ ASMAR 11_ GGVSA 16_ RVLLQ 21_ AARGT 26_ WWNRP 31_ GGTSG 36_ SGEGV 41_ ALGTT 46_ RKFQA 51_ TGSRP 56_ AGEED 61_ AGGPE 66_ RPGDV 71_ VNVVF 76_ VDRSG 81_ QRIPV 86_ SGRVG 91_ DNVLH 96_ LAQRH 101_ GVDLE 106_ GACEA 111_ SLACS 116_ TCHVY 121_ VSEDH 126_ LDLLP 131_ PPEER 136_ EDDML 141_ DMAPL 146_ LQENS 151_ RLGCQ 156_ IVLTP 161_ ELEGA 166_ EFTLP 171_ KITRN 176_ FYVDG 181_HVPKP
1: Electron donor, of the core iron-sulfur cluster (ISC) assembly complex, that acts to reduce the persulfide into sulfide during [2Fe-2S] clusters assembly on the scaffolding protein ISCU (PubMed:28001042). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis (By similarity). This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner (By similarity). Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly (By similarity). Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). Essential for coenzyme Q biosynthesis: together with FDXR, transfers the electrons required for the hydroxylation reaction performed by COQ6 (PubMed:38425362)