ATP synthase subunit C lysine N-methyltransferase (EC 2.1.1.-) (Protein N-lysine methyltransferase FAM173B) (hFAM173B)
1_MEGGG 6_ GIPLE 11_ TLKEE 16_ SQSRH 21_ VLPAS 26_ FEVNS 31_ LQKSN 36_ WGFLL 41_ TGLVG 46_ GTLVA 51_ VYAVA 56_ TPFVT 61_ PALRK 66_ VCLPF 71_ VPATT 76_ KQIEN 81_ VVKML 86_ RCRRG 91_ SLVDI 96_ GSGDG 101_ RIVIA 106_ AAKKG 111_ FTAVG 116_ YELNP 121_ WLVWY 126_ SRYRA 131_ WREGV 136_ HGSAK 141_ FYISD 146_ LWKVT 151_ FSQYS 156_ NVVIF 161_ GVPQM 166_ MLQLE 171_ KKLER 176_ ELEDD 181_ ARVIA 186_ CRFPF 191_ PHWTP 196_ DHVTG 201_ EGIDT 206_ VWAYD 211_ ASTFR 216_ GREKR 221_ PCTSM 226_HFQLP
1: Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, ATP5MC1 and ATP5MC2. Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration (PubMed:29444090, PubMed:30530489). Promotes chronic pain (PubMed:29444090). Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia (PubMed:29444090)