WD repeat-containing protein 73
1_MDPGD 6_ DWLVE 11_ SLRLY 16_ QDFYA 21_ FDLSG 26_ ATRVL 31_ EWIDD 36_ KGVFV 41_ AGYES 46_ LKKNE 51_ ILHLK 56_ LPLRL 61_ SVKEN 66_ KGLFP 71_ ERDFK 76_ VRHGG 81_ FSDRS 86_ IFDLK 91_ HVPHT 96_ RLLVT 101_ SGLPG 106_ CYLQV 111_ WQVAE 116_ DSDVI 121_ KAVST 126_ IAVHE 131_ KEESL 136_ WPRVA 141_ VFSTL 146_ APGVL 151_ HGARL 156_ RSLQV 161_ VDLES 166_ RKTTY 171_ TSDVS 176_ DSEEL 181_ SSLQV 186_ LDADT 191_ FAFCC 196_ ASGRL 201_ GLVDT 206_ RQKWA 211_ PLENR 216_ SPGPG 221_ SGGER 226_ WCAEV 231_ GSWGQ 236_ GPGPS 241_ IASLG 246_ SDGRL 251_ CLLDP 256_ RDLCH 261_ PVSSV 266_ QCPVS 271_ VPSPD 276_ PELLR 281_ VTWAP 286_ GLKNC 291_ LAISG 296_ FDGTV 301_ QVYDA 306_ TSWDG 311_ TRSQD 316_ GTRSQ 321_ VEPLF 326_ THRGH 331_ IFLDG 336_ NGMDP 341_ APLVT 346_ THTWH 351_ PCRPR 356_ TLLSA 361_ TNDAS 366_ LHVWD 371_WVDLC
1: Component of a multiprotein complex required for the assembly of the RNA endonuclease module of the integrator complex (PubMed:39032489). Associates with INTS9 and INTS11 in the cytoplasm, stabilizing the INTS9-INTS11 heterodimer and blocking the active site of INTS11 (PubMed:39032489). BRAT1 then joins the complex and plugs the active site of INTS11, leading to WDR73 release and nuclear import of INTS9 and INTS11 (PubMed:39032489)