Gene name: MZT2A

Uniprot entry:

Q6P582

Protein names:

Mitotic-spindle organizing protein 2A (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2A)

Protein sequence:

1_MAAQG 6_ VGPGP 11_ GSAAP 16_ PGLEA 21_ ARQKL 26_ ALRRK 31_ KVLST 36_ EEMEL 41_ YELAQ 46_ AAGGG 51_ IDPDV 56_ FKILV 61_ DLLKL 66_ NVAPL 71_ AVFQM 76_ LKSMC 81_ AGQRL 86_ ASEPQ 91_ DPAAV 96_ SLPTS 101_ SVPET 106_ RGRDK 111_ GSAAL 116_ GGVLA 121_ LAERS 126_ NHEGS 131_ SQRMP 136_ RQPSA 141_ TRLPK 146_ GGGPG 151_KSPTQ

Protein annotations

Protein functions:

1: Required for the recruitment and the assembly of the gamma-tubulin ring complex (gTuRC) at the centrosome (PubMed:20360068, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:39321809)