Tumor necrosis factor alpha-induced protein 8-like protein 2 (TIPE2) (TNF alpha-induced protein 8-like protein 2) (TNFAIP8-like protein 2) (Inflammation factor protein 20)
1_MESFS 6_ SKSLA 11_ LQAEK 16_ KLLSK 21_ MAGRS 26_ VAHLF 31_ IDETS 36_ SEVLD 41_ ELYRV 46_ SKEYT 51_ HSRPQ 56_ AQRVI 61_ KDLIK 66_ VAIKV 71_ AVLHR 76_ NGSFG 81_ PSELA 86_ LATRF 91_ RQKLR 96_ QGAMT 101_ ALSFG 106_ EVDFT 111_ FEAAV 116_ LAGLL 121_ TECRD 126_ VLLEL 131_ VEHHL 136_ TPKSH 141_ GRIRH 146_ VFDHF 151_ SDPGL 156_ LTALY 161_ GPDFT 166_ QHLGK 171_ ICDGL 176_RKLLD
1: Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis (PubMed:27043859). Plays a regulatory role in the Toll-like signaling pathway by determining the strength of LPS-induced signaling and gene expression (PubMed:32188758). Inhibits TCR-mediated T-cell activation and negatively regulate T-cell function to prevent hyperresponsiveness (By similarity). Also inhibits autolysosome formation via negatively modulating MTOR activation by interacting with RAC1 and promoting the disassociation of the RAC1-MTOR complex (PubMed:32460619). Plays an essential role in NK-cell biology by acting as a checkpoint and displaying an expression pattern correlating with NK-cell maturation process and by negatively regulating NK-cell maturation and antitumor immunity (By similarity). Mechanistically, suppresses IL-15-triggered mTOR activity in NK-cells (By similarity)