Ribonuclease kappa (RNase K) (RNase kappa) (EC 3.1.-.-) (V-type proton ATPase subunit f) (V-ATPase subunit f)
1_MGWLR 6_ PGPRP 11_ LCPPA 16_ RASWA 21_ FSHRF 26_ PSPLA 31_ PRRSP 36_ TPFFM 41_ ASLLC 46_ CGPKL 51_ AACGI 56_ VLSAW 61_ GVIML 66_ IMLGI 71_ FFNVH 76_ SAVLI 81_ EDVPF 86_ TEKDF 91_ ENGPQ 96_ NIYNL 101_ YEQVS 106_ YNCFI 111_ AAGLY 116_ LLLGG 121_ FSFCQ 126_ VRLNK 131_RKEYM
1: Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at a lower rate (PubMed:17881363). Regulates the activity of vacuolar (H+)-ATPase (V-ATPase) which is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:26212330). Required at an early stage of receptor-mediated endocytosis (PubMed:26212330)
2: (Microbial infection) Required at an early stage of both clathrin-mediated and clathrin-independent endocytic uptake of a diverse set of viruses, including dengue, West Nile, Sindbis, Rift Valley Fever, influenza, and human rhinoviruses (PubMed:26056282, PubMed:26212330)