Ankyrin repeat domain-containing protein 16
1_MAQPG 6_ DPRRL 11_ CRLVQ 16_ EGRLR 21_ ALKEE 26_ LQAAG 31_ GCPGP 36_ AGDTL 41_ LHCAA 46_ RHGHR 51_ DVLAY 56_ LAEAW 61_ GMDIE 66_ ATNRD 71_ YKRPL 76_ HEAAS 81_ MGHRD 86_ CVRYL 91_ LGRGA 96_ AVDCL 101_ KKADW 106_ TPLMM 111_ ACTRK 116_ NLGVI 121_ QELVE 126_ HGANP 131_ LLKNK 136_ DGWNS 141_ FHIAS 146_ REGDP 151_ LILQY 156_ LLTVC 161_ PGAWK 166_ TESKI 171_ RRTPL 176_ HTAAM 181_ HGHLE 186_ AVKVL 191_ LKRCQ 196_ YEPDY 201_ RDNCG 206_ VTALM 211_ DAIQC 216_ GHIDV 221_ ARLLL 226_ DEHGA 231_ CLSAE 236_ DSLGA 241_ QALHR 246_ AAVTG 251_ QDEAI 256_ RFLVS 261_ ELGVD 266_ VDVRA 271_ TSTHL 276_ TALHY 281_ AAKEG 286_ HTSTI 291_ QTLLS 296_ LGADI 301_ NSKDE 306_ KNRSA 311_ LHLAC 316_ AGQHL 321_ ACAKF 326_ LLQSG 331_ LKDSE 336_ DITGT 341_ LAQQL 346_ PRRAD 351_ VLQGS 356_GHSAM
1: Required to prevent the misactivation of serine (Ser) with tRNA(Ala) by promoting the hydrolysis of Ser-mischarged tRNA(Ala), thereby playing a role in translational fidelity. Binds directly to the catalytic domain of AARS/AlaRS and captures Ser that is misactivated by AARS/AlaRS, preventing the charging of Ser adenylates to tRNA(Ala) and precluding Ser misincorporation in nascent peptides