Palmitoleoyl-protein carboxylesterase NOTUM (EC 3.1.1.98) (hNOTUM)
1_MGRGV 6_ RVLLL 11_ LSLLH 16_ CAGGS 21_ EGRKT 26_ WRRRG 31_ QQPPP 36_ PPRTE 41_ AAPAA 46_ GQPVE 51_ SFPLD 56_ FTAVE 61_ GNMDS 66_ FMAQV 71_ KSLAQ 76_ SLYPC 81_ SAQQL 86_ NEDLR 91_ LHLLL 96_ NTSVT 101_ CNDGS 106_ PAGYY 111_ LKESR 116_ GSRRW 121_ LLFLE 126_ GGWYC 131_ FNREN 136_ CDSRY 141_ DTMRR 146_ LMSSR 151_ DWPRT 156_ RTGTG 161_ ILSSQ 166_ PEENP 171_ YWWNA 176_ NMVFI 181_ PYCSS 186_ DVWSG 191_ ASSKS 196_ EKNEY 201_ AFMGA 206_ LIIQE 211_ VVREL 216_ LGRGL 221_ SGAKV 226_ LLLAG 231_ SSAGG 236_ TGVLL 241_ NVDRV 246_ AEQLE 251_ KLGYP 256_ AIQVR 261_ GLADS 266_ GWFLD 271_ NKQYR 276_ HTDCV 281_ DTITC 286_ APTEA 291_ IRRGI 296_ RYWNG 301_ VVPER 306_ CRRQF 311_ QEGEE 316_ WNCFF 321_ GYKVY 326_ PTLRC 331_ PVFVV 336_ QWLFD 341_ EAQLT 346_ VDNVH 351_ LTGQP 356_ VQEGL 361_ RLYIQ 366_ NLGRE 371_ LRHTL 376_ KDVPA 381_ SFAPA 386_ CLSHE 391_ IIIRS 396_ HWTDV 401_ QVKGT 406_ SLPRA 411_ LHCWD 416_ RSLHD 421_ SHKAS 426_ KTPLK 431_ GCPVH 436_ LVDSC 441_ PWPHC 446_ NPSCP 451_ TVRDQ 456_ FTGQE 461_ MNVAQ 466_ FLMHM 471_ GFDMQ 476_ TVAQP 481_ QGLEP 486_ SELLG 491_MLSNG
1: Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175)