Integrator complex subunit 5 (Int5)
1_MSALC 6_ DPPGA 11_ PGPPG 16_ PAPAT 21_ HGPAP 26_ LSAQE 31_ LSQEI 36_ KAFLT 41_ GVDPI 46_ LGHQL 51_ SAREH 56_ ARCGL 61_ LLLRS 66_ LPPAR 71_ AAVLD 76_ HLRGV 81_ FDESV 86_ RAHLA 91_ ALDET 96_ PVAGP 101_ PHLRP 106_ PPPSH 111_ VPAGG 116_ PGLED 121_ VVQEV 126_ QQVLS 131_ EFIRA 136_ NPKAW 141_ APVIS 146_ AWSID 151_ LMGQL 156_ SSTYS 161_ GQHQR 166_ VPHAT 171_ GALNE 176_ LLQLW 181_ MGCRA 186_ TRTLM 191_ DIYVQ 196_ CLSAL 201_ IGSCP 206_ DACVD 211_ ALLDT 216_ SVQHS 221_ PHFDW 226_ VVAHI 231_ GSSFP 236_ GTIIS 241_ RVLSC 246_ GLKDF 251_ CVHGG 256_ AGGGA 261_ GSSGG 266_ SSSQT 271_ PSTDP 276_ FPGSP 281_ AIPAE 286_ KRVPK 291_ IASVV 296_ GILGH 301_ LASRH 306_ GDSIR 311_ RELLR 316_ MFHDS 321_ LAGGS 326_ GGRSG 331_ DPSLQ 336_ ATVPF 341_ LLQLA 346_ VMSPA 351_ LLGTV 356_ SGELV 361_ DCLKP 366_ PAVLS 371_ QLQQH 376_ LQGFP 381_ REELD 386_ NMLNL 391_ AVHLV 396_ SQASG 401_ AGAYR 406_ LLQFL 411_ VDTAM 416_ PASVI 421_ TTQGL 426_ AVPDT 431_ VREAC 436_ DRLIQ 441_ LLLLH 446_ LQKLV 451_ HHRGG 456_ SPGEG 461_ VLGPP 466_ PPPRL 471_ VPFLD 476_ ALKNH 481_ VGELC 486_ GETLR 491_ LERKR 496_ FLWQH 501_ QLLGL 506_ LSVYT 511_ RPSCG 516_ PEALG 521_ HLLSR 526_ ARSPE 531_ ELSLA 536_ TQLYA 541_ GLVVS 546_ LSGLL 551_ PLAFR 556_ SCLAR 561_ VHAGT 566_ LQPPF 571_ TARFL 576_ RNLAL 581_ LVGWE 586_ QQGGE 591_ GPAAL 596_ GAHFG 601_ ESASA 606_ HLSDL 611_ APLLL 616_ HPEEE 621_ VAEAA 626_ ASLLA 631_ ICPFP 636_ SEALS 641_ PSQLL 646_ GLVRA 651_ GVHRF 656_ FASLR 661_ LHGPP 666_ GVASA 671_ CQLLT 676_ RLSQT 681_ SPAGL 686_ KAVLQ 691_ LLVEG 696_ ALHRG 701_ NTELF 706_ GGQVD 711_ GDNET 716_ LSVVS 721_ ASLAS 726_ ASLLD 731_ TNRRH 736_ TAAVP 741_ GPGGI 746_ WSVFH 751_ AGVIG 756_ RGLKP 761_ PKFVQ 766_ SRNQQ 771_ EVIYN 776_ TQSLL 781_ SLLVH 786_ CCSAP 791_ GGTEC 796_ GECWG 801_ APILS 806_ PEAAK 811_ AVAVT 816_ LVESV 821_ CPDAA 826_ GAELA 831_ WPPEE 836_ HARAT 841_ VERDL 846_ RIGRR 851_ FREQP 856_ LLFEL 861_ LKLVA 866_ AAPPA 871_ LCYCS 876_ VLLRG 881_ LLAAL 886_ LGHWE 891_ ASRHP 896_ DTTHS 901_ PWHLE 906_ ASCTL 911_ VAVMA 916_ EGSLL 921_ PPALG 926_ NMHEV 931_ FSQLA 936_ PFEVR 941_ LLLLS 946_ VWGFL 951_ REHGP 956_ LPQKF 961_ IFQSE 966_ RGRFI 971_ RDFSR 976_ EGGGE 981_ GGPHL 986_ AVLHS 991_ VLHRN 996_ IDRLG 1001_ LFSGR 1006_ FQAPS 1011_PSTLL
1: Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:33243860, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860, PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267)