E3 ubiquitin ligase TRIM40 (EC 2.3.2.27) (Probable E3 NEDD8-protein ligase) (RING finger protein 35)
1_MIPLQ 6_ KDNQE 11_ EGVCP 16_ ICQES 21_ LKEAV 26_ STNCG 31_ HLFCR 36_ VCLTQ 41_ HVEKA 46_ SASGV 51_ FCCPL 56_ CRKPC 61_ SEEVL 66_ GTGYI 71_ CPNHQ 76_ KRVCR 81_ FCEES 86_ RLLLC 91_ VECLV 96_ SPEHM 101_ SHHEL 106_ TIENA 111_ LSHYK 116_ ERLNR 121_ RSRKL 126_ RKDIA 131_ ELQRL 136_ KAQQE 141_ KKLQA 146_ LQFQV 151_ DHGNH 156_ RLEAG 161_ PESQH 166_ QTREQ 171_ LGALP 176_ QQWLG 181_ QLEHM 186_ PAEAA 191_ RILDI 196_ SRAVT 201_ QLRSL 206_ VIDLE 211_ RTAKE 216_ LDTNT 221_ LKNAG 226_ DLLNR 231_ SAPQK 236_ LEVIY 241_ PQLEK 246_ GVSEL 251_LLQPP
1: E3 ubiquitin-protein ligase that plays a role in the limitation of the innate immune response (PubMed:21474709, PubMed:29117565). Mediates inhibition of the RLR signaling pathway by ubiquitinating RIGI and IFIH1 receptors, leading to their proteasomal degradation (PubMed:21474709). Also promotes the neddylation of IKBKG/NEMO, stabilizing NFKBIA, and thereby inhibiting of NF-kappa-B nuclear translocation and activation (PubMed:21474709)