Long-chain fatty acid transport protein 1 (FATP-1) (Fatty acid transport protein 1) (EC 6.2.1.15) (Solute carrier family 27 member 1)
1_MRAPG 6_ AGAAS 11_ VVSLA 16_ LLWLL 21_ GLPWT 26_ WSAAA 31_ ALGVY 36_ VGSGG 41_ WRFLR 46_ IVCKT 51_ ARRDL 56_ FGLSV 61_ LIRVR 66_ LELRR 71_ HQRAG 76_ HTIPR 81_ IFQAV 86_ VQRQP 91_ ERLAL 96_ VDAGT 101_ GECWT 106_ FAQLD 111_ AYSNA 116_ VANLF 121_ RQLGF 126_ APGDV 131_ VAIFL 136_ EGRPE 141_ FVGLW 146_ LGLAK 151_ AGMEA 156_ ALLNV 161_ NLRRE 166_ PLAFC 171_ LGTSG 176_ AKALI 181_ FGGEM 186_ VAAVA 191_ EVSGH 196_ LGKSL 201_ IKFCS 206_ GDLGP 211_ EGILP 216_ DTHLL 221_ DPLLK 226_ EASTA 231_ PLAQI 236_ PSKGM 241_ DDRLF 246_ YIYTS 251_ GTTGL 256_ PKAAI 261_ VVHSR 266_ YYRMA 271_ AFGHH 276_ AYRMQ 281_ AADVL 286_ YDCLP 291_ LYHSA 296_ GNIIG 301_ VGQCL 306_ IYGLT 311_ VVLRK 316_ KFSAS 321_ RFWDD 326_ CIKYN 331_ CTVVQ 336_ YIGEI 341_ CRYLL 346_ KQPVR 351_ EAERR 356_ HRVRL 361_ AVGNG 366_ LRPAI 371_ WEEFT 376_ ERFGV 381_ RQIGE 386_ FYGAT 391_ ECNCS 396_ IANMD 401_ GKVGS 406_ CGFNS 411_ RILPH 416_ VYPIR 421_ LVKVN 426_ EDTME 431_ LLRDA 436_ QGLCI 441_ PCQAG 446_ EPGLL 451_ VGQIN 456_ QQDPL 461_ RRFDG 466_ YVSES 471_ ATSKK 476_ IAHSV 481_ FSKGD 486_ SAYLS 491_ GDVLV 496_ MDELG 501_ YMYFR 506_ DRSGD 511_ TFRWR 516_ GENVS 521_ TTEVE 526_ GVLSR 531_ LLGQT 536_ DVAVY 541_ GVAVP 546_ GVEGK 551_ AGMAA 556_ VADPH 561_ SLLDP 566_ NAIYQ 571_ ELQKV 576_ LAPYA 581_ RPIFL 586_ RLLPQ 591_ VDTTG 596_ TFKIQ 601_ KTRLQ 606_ REGFD 611_ PRQTS 616_ DRLFF 621_ LDLKQ 626_ GHYLP 631_ LNEAV 636_ YTRIC 641_SGAFA
1: Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane (PubMed:12556534, PubMed:20530735, PubMed:21395585, PubMed:28178239). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism (By similarity). Probably involved in fatty acid transport across the blood barrier (PubMed:21395585)