E3 ubiquitin-protein ligase RFWD3 (EC 2.3.2.27) (RING finger and WD repeat domain-containing protein 3) (RING finger protein 201)
1_MAHEA 6_ MEYDV 11_ QVQLN 16_ HAEQQ 21_ PAPAG 26_ MASSQ 31_ GGPAL 36_ LQPVP 41_ ADVVS 46_ SQGVP 51_ SILQP 56_ APAEV 61_ ISSQA 66_ TPPLL 71_ QPAPQ 76_ LSVDL 81_ TEVEV 86_ LGEDT 91_ VENIN 96_ PRTSE 101_ QHRQG 106_ SDGNH 111_ TIPAS 116_ SLHSM 121_ TNFIS 126_ GLQRL 131_ HGMLE 136_ FLRPS 141_ SSNHS 146_ VGPMR 151_ TRRRV 156_ SASRR 161_ ARAGG 166_ SQRTD 171_ SARLR 176_ APLDA 181_ YFQVS 186_ RTQPD 191_ LPATT 196_ YDSET 201_ RNPVS 206_ EELQV 211_ SSSSD 216_ SDSDS 221_ SAEYG 226_ GVVDQ 231_ AEESG 236_ AVILE 241_ EQLAG 246_ VSAEQ 251_ EVTCI 256_ DGGKT 261_ LPKQP 266_ SPQKS 271_ EPLLP 276_ SASMD 281_ EEEGD 286_ TCTIC 291_ LEQWT 296_ NAGDH 301_ RLSAL 306_ RCGHL 311_ FGYRC 316_ ISTWL 321_ KGQVR 326_ KCPQC 331_ NKKAR 336_ HSDIV 341_ VLYAR 346_ TLRAL 351_ DTSEQ 356_ ERMKS 361_ SLLKE 366_ QMLRK 371_ QAELE 376_ SAQCR 381_ LQLQV 386_ LTDKC 391_ TRLQR 396_ RVQDL 401_ QKLTS 406_ HQSQN 411_ LQQPR 416_ GSQAW 421_ VLSCS 426_ PSSQG 431_ QHKHK 436_ YHFQK 441_ TFTVS 446_ QAGNC 451_ RIMAY 456_ CDALS 461_ CLVIS 466_ QPSPQ 471_ ASFLP 476_ GFGVK 481_ MLSTA 486_ NMKSS 491_ QYIPM 496_ HGKQI 501_ RGLAF 506_ SSYLR 511_ GLLLS 516_ ASLDN 521_ TIKLT 526_ SLETN 531_ TVVQT 536_ YNAGR 541_ PVWSC 546_ CWCLD 551_ EANYI 556_ YAGLA 561_ NGSIL 566_ VYDVR 571_ NTSSH 576_ VQELV 581_ AQKAR 586_ CPLVS 591_ LSYMP 596_ RAASA 601_ AFPYG 606_ GVLAG 611_ TLEDA 616_ SFWEQ 621_ KMDFS 626_ HWPHV 631_ LPLEP 636_ GGCID 641_ FQTEN 646_ SSRHC 651_ LVTYR 656_ PDKNH 661_ TTIRS 666_ VLMEM 671_ SYRLD 676_ DTGNP 681_ ICSCQ 686_ PVHTF 691_ FGGPT 696_ CKLLT 701_ KNAIF 706_ QSPEN 711_ DGNIL 716_ VCTGD 721_ EAANS 726_ ALLWD 731_ AASGS 736_ LLQDL 741_ QTDQP 746_ VLDIC 751_ PFEVN 756_ RNSYL 761_ ATLTE 766_KMVHI
1: E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage (PubMed:21504906, PubMed:21558276, PubMed:26474068, PubMed:28575657, PubMed:28575658, PubMed:33321094). Plays a key role in RPA-mediated DNA damage signaling and repair (PubMed:21504906, PubMed:21558276, PubMed:26474068, PubMed:28575657, PubMed:28575658, PubMed:28691929). Acts by mediating ubiquitination of the RPA complex (RPA1, RPA2 and RPA3 subunits) and RAD51 at stalled replication forks, leading to remove them from DNA damage sites and promote homologous recombination (PubMed:26474068, PubMed:28575657, PubMed:28575658). Also mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint (PubMed:20173098). May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome (PubMed:20173098). In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53 (PubMed:20173098). Required to translesion DNA synthesis across DNA-protein cross-link adducts by catalyzing ubiquitination of proteins on single-stranded DNA (ssDNA) (PubMed:33321094)