RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1)
1_MSRGS 6_ IEIPL 11_ RDTDE 16_ VIELD 21_ FDQLP 26_ EGDEV 31_ ISILK 36_ QEHTQ 41_ LHIWI 46_ ALALE 51_ YYKQG 56_ KTEEF 61_ VKLLE 66_ AARID 71_ GNLDY 76_ RDHEK 81_ DQMTC 86_ LDTLA 91_ AYYVQ 96_ QARKE 101_ KNKDN 106_ KKDLI 111_ TQATL 116_ LYTMA 121_ DKIIM 126_ YDQNH 131_ LLGRA 136_ CFCLL 141_ EGDKM 146_ DQADA 151_ QFHFV 156_ LNQSP 161_ NNIPA 166_ LLGKA 171_ CISFN 176_ KKDYR 181_ GALAY 186_ YKKAL 191_ RTNPG 196_ CPAEV 201_ RLGMG 206_ HCFVK 211_ LNKLE 216_ KARLA 221_ FSRAL 226_ ELNSK 231_ CVGAL 236_ VGLAV 241_ LELNN 246_ KEADS 251_ IKNGV 256_ QLLSR 261_ AYTID 266_ PSNPM 271_ VLNHL 276_ ANHFF 281_ FKKDY 286_ SKVQH 291_ LALHA 296_ FHNTE 301_ VEAMQ 306_ AESCY 311_ QLARS 316_ FHVQE 321_ DYDQA 326_ FQYYY 331_ QATQF 336_ ASSSF 341_ VLPFF 346_ GLGQM 351_ YIYRG 356_ DKENA 361_ SQCFE 366_ KVLKA 371_ YPNNY 376_ ETMKI 381_ LGSLY 386_ AASED 391_ QEKRD 396_ IAKGH 401_ LKKVT 406_ EQYPD 411_ DVEAW 416_ IELAQ 421_ ILEQT 426_ DIQGA 431_ LSAYG 436_ TATRI 441_ LQEKV 446_ QADVP 451_ PEILN 456_ NVGAL 461_ HFRLG 466_ NLGEA 471_ KKYFL 476_ ASLDR 481_ AKAEA 486_ EHDEH 491_ YYNAI 496_ SVTTS 501_ YNLAR 506_ LYEAM 511_ CEFHE 516_ AEKLY 521_ KNILR 526_ EHPNY 531_ VDCYL 536_ RLGAM 541_ ARDKG 546_ NFYEA 551_ SDWFK 556_ EALQI 561_ NQDHP 566_ DAWSL 571_ IGNLH 576_ LAKQE 581_ WGPGQ 586_ KKFER 591_ ILKQP 596_ STQSD 601_ TYSML 606_ ALGNV 611_ WLQTL 616_ HQPTR 621_ DREKE 626_ KRHQD 631_ RALAI 636_ YKQVL 641_ RNDAK 646_ NLYAA 651_ NGIGA 656_ VLAHK 661_ GYFRE 666_ ARDVF 671_ AQVRE 676_ ATADI 681_ SDVWL 686_ NLAHI 691_ YVEQK 696_ QYISA 701_ VQMYE 706_ NCLRK 711_ FYKHQ 716_ NTEVV 721_ LYLAR 726_ ALFKC 731_ GKLQE 736_ CKQTL 741_ LKARH 746_ VAPSD 751_ TVLMF 756_ NVALV 761_ LQRLA 766_ TSVLK 771_ DEKSN 776_ LKEVL 781_ NAVKE 786_ LELAH 791_ RYFSY 796_ LSKVG 801_ DKMRF 806_ DLALA 811_ ATEAR 816_ QCSDL 821_ LSQAQ 826_ YHVAR 831_ ARKQD 836_ EEERE 841_ LRAKQ 846_ EQEKE 851_ LLRQK 856_ LLKEQ 861_ EEKRL 866_ REKEE 871_ QKKLL 876_ EQRAQ 881_ YVEKT 886_ KNILM 891_ FTGET 896_ EATKE 901_ KKRGG 906_ GGGRR 911_ SKKGG 916_ EFDEF 921_ VNDDT 926_ DDDLP 931_ ISKKK 936_ KRRKG 941_ SGSEQ 946_ EGEDE 951_ EGGER 956_ KKKKR 961_ RRHPK 966_ GEEGS 971_ DDDET 976_ ENGPK 981_ PKKRR 986_ PPKAE 991_ KKKAP 996_ KPERL 1001_ PPSMK 1006_ GKIKS 1011_ KAIIS 1016_ SSDDS 1021_ SDEDK 1026_ LKIAD 1031_ EGHPR 1036_ NSNSN 1041_ SDSDE 1046_ DEQRK 1051_ KCASS 1056_ ESDSD 1061_ ENQNK 1066_ SGSEA 1071_ GSPRR 1076_ PRRQR 1081_ SDQDS 1086_ DSDQP 1091_ SRKRR 1096_ PSGSE 1101_ QSDNE 1106_ SVQSG 1111_ RSHSG 1116_ VSEND 1121_ SRPAS 1126_ PSAES 1131_ DHESE 1136_ RGSDN 1141_ EGSGQ 1146_ GSGNE 1151_ SEPEG 1156_ SNNEA 1161_ SDRGS 1166_EHGSD
1: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3) and dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3 (By similarity)