Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 1) (Histidine acid phosphatase domain-containing protein 2A) (IP6 kinase) (Inositol pyrophosphate synthase 1) (InsP6 and PP-IP5 kinase 1) (VIP1 homolog) (hsVIP1)
1_MWSLT 6_ ASEGE 11_ STTAH 16_ FFLGA 21_ GDEGL 26_ GTRGI 31_ GMRPE 36_ ESDSE 41_ LLEDE 46_ EDEVP 51_ PEPQI 56_ IVGIC 61_ AMTKK 66_ SKSKP 71_ MTQIL 76_ ERLCR 81_ FDYLT 86_ VVILG 91_ EDVIL 96_ NEPVE 101_ NWPSC 106_ HCLIS 111_ FHSKG 116_ FPLDK 121_ AVAYS 126_ KLRNP 131_ FLIND 136_ LAMQY 141_ YIQDR 146_ REVYR 151_ ILQEE 156_ GIDLP 161_ RYAVL 166_ NRDPA 171_ RPEEC 176_ NLIEG 181_ EDQVE 186_ VNGAV 191_ FPKPF 196_ VEKPV 201_ SAEDH 206_ NVYIY 211_ YPSSA 216_ GGGSQ 221_ RLFRK 226_ IGSRS 231_ SVYSP 236_ ESSVR 241_ KTGSY 246_ IYEEF 251_ MPTDG 256_ TDVKV 261_ YTVGP 266_ DYAHA 271_ EARKS 276_ PALDG 281_ KVERD 286_ SEGKE 291_ IRYPV 296_ MLTAM 301_ EKLVA 306_ RKVCV 311_ AFKQT 316_ VCGFD 321_ LLRAN 326_ GHSFV 331_ CDVNG 336_ FSFVK 341_ NSMKY 346_ YDDCA 351_ KILGN 356_ TIMRE 361_ LAPQF 366_ QIPWS 371_ IPTEA 376_ EDIPI 381_ VPTTS 386_ GTMME 391_ LRCVI 396_ AIIRH 401_ GDRTP 406_ KQKMK 411_ MEVKH 416_ PRFFA 421_ LFEKH 426_ GGYKT 431_ GKLKL 436_ KRPEQ 441_ LQEVL 446_ DITRL 451_ LLAEL 456_ EKEPG 461_ GEIEE 466_ KTGKL 471_ EQLKS 476_ VLEMY 481_ GHFSG 486_ INRKV 491_ QLTYY 496_ PHGVK 501_ ASNEG 506_ QDPQR 511_ ETLAP 516_ SLLLV 521_ LKWGG 526_ ELTPA 531_ GRVQA 536_ EELGR 541_ AFRCM 546_ YPGGQ 551_ GDYAG 556_ FPGCG 561_ LLRLH 566_ STFRH 571_ DLKIY 576_ ASDEG 581_ RVQMT 586_ AAAFA 591_ KGLLA 596_ LEGEL 601_ TPILV 606_ QMVKS 611_ ANMNG 616_ LLDSD 621_ GDSLS 626_ SCQHR 631_ VKARL 636_ HHILQ 641_ QDAPF 646_ GPEDY 651_ DQLAP 656_ TRSTS 661_ LLNSM 666_ TIIQN 671_ PVKVC 676_ DQVFA 681_ LIENL 686_ THQIR 691_ ERMQD 696_ PRSVD 701_ LQLYH 706_ SETLE 711_ LMLQR 716_ WSKLE 721_ RDFRQ 726_ KSGRY 731_ DISKI 736_ PDIYD 741_ CVKYD 746_ VQHNG 751_ SLGLQ 756_ GTAEL 761_ LRLSK 766_ ALADV 771_ VIPQE 776_ YGISR 781_ EEKLE 786_ IAVGF 791_ CLPLL 796_ RKILL 801_ DLQRT 806_ HEDES 811_ VNKLH 816_ PLCYL 821_ RYSRG 826_ VLSPG 831_ RHVRT 836_ RLYFT 841_ SESHV 846_ HSLLS 851_ VFRYG 856_ GLLDE 861_ TQDAQ 866_ WQRAL 871_ DYLSA 876_ ISELN 881_ YMTQI 886_ VIMLY 891_ EDNTQ 896_ DPLSE 901_ ERFHV 906_ ELHFS 911_ PGVKG 916_ VEEEG 921_ SAPAG 926_ CGFRP 931_ ASSEN 936_ EEMKT 941_ NQGSM 946_ ENLCP 951_ GKASD 956_ EPDRA 961_ LQTSP 966_ QPPEG 971_ PGLPR 976_ RSPLI 981_ RNRKA 986_ GSMEV 991_ LSETS 996_ SSRPG 1001_ GYRLF 1006_ SSSRP 1011_ PTEMK 1016_ QSGLG 1021_ SQCTG 1026_ LFSTT 1031_ VLGGS 1036_ SSAPN 1041_ LQDYA 1046_ RSHGK 1051_ KLPPA 1056_ SLKHR 1061_ DELLF 1066_ VPAVK 1071_ RFSVS 1076_ FAKHP 1081_ TNGFE 1086_ GCSMV 1091_ PTIYP 1096_ LETLH 1101_ NALSL 1106_ RQVSE 1111_ FLSRV 1116_ CQRHT 1121_ DAQAQ 1126_ ASAAL 1131_ FDSMH 1136_ SSQAS 1141_ DNPFS 1146_ PPRTL 1151_ HSPPL 1156_ QLQQR 1161_ SEKPP 1166_ WYSSG 1171_ PSSTV 1176_ SSAGP 1181_ SSPTT 1186_ VDGNS 1191_ QFGFS 1196_ DQPSL 1201_ NSHVA 1206_ EEHQG 1211_ LGLLQ 1216_ ETPGS 1221_ GAQEL 1226_ SIEGE 1231_ QELFE 1236_ PNQSP 1241_ QVPPM 1246_ ETSQP 1251_ YEEVS 1256_ QPCQE 1261_ VPDIS 1266_ QPCQD 1271_ ISEAL 1276_ SQPCQ 1281_ KVPDI 1286_ SQQCQ 1291_ ENHDN 1296_ GNHTC 1301_ QEVPH 1306_ ISQPC 1311_ QKSSQ 1316_ LCQKV 1321_ SEEVC 1326_ QLCLE 1331_ NSEEV 1336_ SQPCQ 1341_ GVSVE 1346_ VGKLV 1351_ HKFHV 1356_ GVGSL 1361_ VQETL 1366_ VEVGS 1371_ PAEEI 1376_ PEEVI 1381_ QPYQE 1386_ FSVEV 1391_ GRLAQ 1396_ ETSAI 1401_ NLLSQ 1406_ GIPEI 1411_ DKPSQ 1416_ EFPEE 1421_ IDLQA 1426_QEVPE
1: Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress