Proline/serine-rich coiled-coil protein 1
1_MEDLE 6_ EDVRF 11_ IVDET 16_ LDFGG 21_ LSPSD 26_ SREEE 31_ DITVL 36_ VTPEK 41_ PLRRG 46_ LSHRS 51_ DPNAV 56_ APAPQ 61_ GVRLS 66_ LGPLS 71_ PEKLE 76_ EILDE 81_ ANRLA 86_ AQLEQ 91_ CALQD 96_ RESAG 101_ EGLGP 106_ RRVKP 111_ SPRRE 116_ TFVLK 121_ DSPVR 126_ DLLPT 131_ VNSLT 136_ RSTPS 141_ PSSLT 146_ PRLRS 151_ NDRKG 156_ SVRAL 161_ RATSG 166_ KRPSN 171_ MKRES 176_ PTCNL 181_ FPASK 186_ SPASS 191_ PLTRS 196_ TPPVR 201_ GRAGP 206_ SGRAA 211_ ASEET 216_ RAAKL 221_ RVSGS 226_ GEFVG 231_ LTLKF 236_ LHPSP 241_ PGPPT 246_ PIRSV 251_ LAPQP 256_ STSNS 261_ QRLPR 266_ PQGAA 271_ AKSSS 276_ QLPIP 281_ SAIPR 286_ PASRM 291_ PLTSR 296_ SVPPG 301_ RGALP 306_ PDSLS 311_ TRKGL 316_ PRPST 321_ AGHRV 326_ RESGH 331_ KVPVS 336_ QRLNL 341_ PVMGA 346_ TRSNL 351_ QPPRK 356_VAVPG
1: Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression