Tetratricopeptide repeat protein 37 (TPR repeat protein 37) (SKI3 homolog) (Ski3) (Tricho-hepatic-enteric syndrome protein) (Thespin)
1_MSSKE 6_ VKTAL 11_ KSARD 16_ AIRNK 21_ EYKEA 26_ LKHCK 31_ TVLKQ 36_ EKNNY 41_ NAWVF 46_ IGVAA 51_ AELEQ 56_ PDQAQ 61_ SAYKK 66_ AAELE 71_ PDQLL 76_ AWQGL 81_ ANLYE 86_ KYNHI 91_ NAKDD 96_ LPGVY 101_ QKLLD 106_ LYESV 111_ DKQKW 116_ CDVCK 121_ KLVDL 126_ YYQEK 131_ KHLEV 136_ ARTWH 141_ KLIKT 146_ RQEQG 151_ AENEE 156_ LHQLW 161_ RKLTQ 166_ FLAES 171_ TEDQN 176_ NETQQ 181_ LLFTA 186_ FENAL 191_ GLSDK 196_ IPSED 201_ HQVLY 206_ RHFIQ 211_ SLSKF 216_ PHESA 221_ RLKKA 226_ CEGMI 231_ NIYPT 236_ VQYPL 241_ EVLCL 246_ HLIES 251_ GNLTD 256_ EGQQY 261_ CCRLV 266_ EMDSK 271_ SGPGL 276_ IGLGI 281_ KALQD 286_ KKYED 291_ AVRNL 296_ TEGLK 301_ ESPVC 306_ TSGWY 311_ HLAEA 316_ QVKMH 321_ RPKEA 326_ VLSCS 331_ QALKI 336_ VDNLG 341_ ASGNS 346_ LYQRN 351_ LCLHL 356_ KAEAL 361_ IKLSD 366_ YDSSE 371_ EAIRT 376_ LDQIS 381_ DADNI 386_ PGLLV 391_ LKSLA 396_ YRNKG 401_ SFDEA 406_ AKIME 411_ DLLSS 416_ YPDLA 421_ EVHAL 426_ EALIH 431_ FTKKD 436_ YLQAE 441_ KCFQR 446_ ALEKD 451_ TEVAE 456_ YHYQL 461_ GLTYW 466_ FMGEE 471_ TRKDK 476_ TKALT 481_ HFLKA 486_ ARLDT 491_ YMGKV 496_ FCYLG 501_ HYYRD 506_ VVGDK 511_ NRARG 516_ CYRKA 521_ FELDD 526_ TDAES 531_ GAAAV 536_ DLSVE 541_ LEDME 546_ MALAI 551_ LTTVT 556_ QKASA 561_ GTAKW 566_ AWLRR 571_ GLYYL 576_ KAGQH 581_ SQAVA 586_ DLQAA 591_ LRADP 596_ KDFNC 601_ WESLG 606_ EAYLS 611_ RGGYT 616_ TALKS 621_ FTKAS 626_ ELNPE 631_ SIYSV 636_ FKVAA 641_ IQQIL 646_ GKYKE 651_ AVAQY 656_ QMIIK 661_ KKEDY 666_ VPALK 671_ GLGEC 676_ HLMMA 681_ KAALV 686_ DYLDG 691_ KAVDY 696_ IEKAL 701_ EYFTC 706_ ALQHR 711_ ADVSC 716_ LWKLA 721_ GDACT 726_ CLYAV 731_ APSKV 736_ NVHVL 741_ GVLLG 746_ QKEGK 751_ QVLKK 756_ NELLH 761_ LGGRC 766_ YGRAL 771_ KLMST 776_ SNTWC 781_ DLGIN 786_ YYRQA 791_ QHLAE 796_ TGSNM 801_ NDLKE 806_ LLEKS 811_ LHCLK 816_ KAVRL 821_ DSNNH 826_ LYWNA 831_ LGVVA 836_ CYSGI 841_ GNYAL 846_ AQHCF 851_ IKSIQ 856_ SEQIN 861_ AVAWT 866_ NLGVL 871_ YLTNE 876_ NIEQA 881_ HEAFK 886_ MAQSL 891_ DPSYL 896_ MCWIG 901_ QALIA 906_ EAVGS 911_ YDTMD 916_ LFRHT 921_ TELNM 926_ HTEGA 931_ LGYAY 936_ WVCTT 941_ LQDKS 946_ NRETE 951_ LYQYN 956_ ILQMN 961_ AIPAA 966_ QVILN 971_ KYVER 976_ IQNYA 981_ PAFTM 986_ LGYLN 991_ EHLQL 996_ KKEAA 1001_ NAYQR 1006_ AILLL 1011_ QTAED 1016_ QDTYN 1021_ VAIRN 1026_ YGRLL 1031_ CSTGE 1036_ YDKAI 1041_ QAFKS 1046_ TPLEV 1051_ LEDII 1056_ GFALA 1061_ LFMKG 1066_ LYKES 1071_ SKAYE 1076_ RALSI 1081_ VESEQ 1086_ DKAHI 1091_ LTALA 1096_ ITEYK 1101_ QGKTD 1106_ VAKTL 1111_ LFKCS 1116_ ILKEP 1121_ TTESL 1126_ QALCA 1131_ LGLAM 1136_ QDATL 1141_ SKAAL 1146_ NELLK 1151_ HIKHK 1156_ DSNYQ 1161_ RCLLT 1166_ SAIYA 1171_ LQGRS 1176_ VAVQK 1181_ QISKA 1186_ VHSNP 1191_ GDPAL 1196_ WSLLS 1201_ RVVAQ 1206_ YAQRN 1211_ AKGGV 1216_ VAGNV 1221_ AHILD 1226_ SNHGK 1231_ KALLY 1236_ TAVNQ 1241_ LAMGS 1246_ SSAED 1251_ EKNTA 1256_ LKTIQ 1261_ KAALL 1266_ SPGDP 1271_ AIWAG 1276_ LMAAC 1281_ HADDK 1286_ LALVN 1291_ NTQPK 1296_ RIDLY 1301_ LALLS 1306_ AVSAS 1311_ IKDEK 1316_ FFENY 1321_ NQSLE 1326_ KWSLS 1331_ QAVTG 1336_ LIDTG 1341_ RISEA 1346_ ETLCT 1351_ KNLKS 1356_ NPDQP 1361_ AVILL 1366_ LRQVQ 1371_ CKPLL 1376_ ESQKP 1381_ LPDAV 1386_ LEELQ 1391_ KTVMS 1396_ NSTSV 1401_ PAWQW 1406_ LAHVY 1411_ QSQGM 1416_ MRAAE 1421_ MCYRK 1426_ SLQLA 1431_ SQRGS 1436_ WSGKL 1441_ SSLLR 1446_ LALLA 1451_ LKVCM 1456_ ANISN 1461_ DHWPS 1466_ LVQEA 1471_ TTEAL 1476_ KLCFC 1481_ PLAVL 1486_ LQALL 1491_ QFKRK 1496_ MGARE 1501_ TRRLL 1506_ ERVVY 1511_ QPGYP 1516_ KSIAS 1521_ TARWY 1526_ LLRHL 1531_ YAKDD 1536_ YELID 1541_ VLVNN 1546_ AKTHG 1551_ DTRAL 1556_ELNQR
1: Component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways (PubMed:16024656, PubMed:32006463, PubMed:35120588). The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation (PubMed:32006463, PubMed:35120588). SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling (PubMed:32006463). In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C) (PubMed:16024656)